Catalog No.
Product Name
Application
Product Information
Citations
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FXR Agonist
FXR Agonist 12 is a selective agonist for the farnesoid X receptor (FXR). It effectively down-regulates genes associated with bile acid synthesis while up-regulating those involved in bile acid transport in HepG2 cells. In preclinical studies, FXR Agonist 12 has demonstrated the capability to improve cholestasis induced by ANIT and to mitigate liver damage and fibrosis in mouse models of non-alcoholic steatohepatitis (NASH). This compound is instrumental for research focusing on liver disorders and bile acid metabolism. -
FXR Agonist
Alismanol M is a farnesoid X receptor (FXR) agonist, exhibiting an EC50 value of 50.25 μM. This protostane-type triterpenoid, derived from the rhizome of Alisma orientale, plays a significant role in modulating bile acid homeostasis. Alismanol M is valuable for research into cholestasis and nonalcoholic steatohepatitis, providing insights into liver metabolism and disease mechanisms. -
FXR Agonist
LZ-007 is a highly selective agonist of the farnesoid X receptor (FXR), exhibiting an EC50 of 51 nM in TR-FRET assays and 76 nM in HepG2 cells. This compound demonstrates favorable pharmacokinetic properties in SD rats. LZ-007 has shown efficacy in ameliorating metabolic dysfunction associated with steatohepatitis in models of western diet and CCl4-induced mice, making it a valuable tool for research in metabolic diseases and liver dysfunction. -
FXR Agonist
XJ02862-S2 is a potent agonist of the farnesoid X receptor (FXR). It demonstrates significant biological activity and holds promise as a lead compound in research focused on non-alcoholic fatty liver disease (NAFLD). XJ02862-S2 may serve as a valuable tool for elucidating the role of FXR in metabolic disorders and developing therapeutic strategies for liver-related diseases. -
FXR Agonist
Ferolin is an agonist of the farnesoid X receptor (FXR), exhibiting an EC50 of 0.56 µM. This compound effectively inhibits the expression of pro-inflammatory genes, including iNOS, IL-1β, and TNFα, upon FXR activation. Ferolin is valuable for research focused on metabolic regulation, inflammation, and related therapeutic pathways. -
FXR Antagonist
FXR Antagonist 2 is a diarylamide derivative that serves as a moderate antagonist of the farnesoid X receptor (FXR). This compound demonstrates potential in the investigation of metabolic disorders, specifically hyperlipidemia and type 2 diabetes. Its ability to modulate FXR activity makes it a valuable tool for exploring therapeutic strategies targeting these conditions. -
FXR
GSK8062 is a potent agonist of the farnesoid X receptor (FXR), involved in the regulation of bile acid and lipid metabolism. This compound has demonstrated significant biological activity, including the reduction of weight gain and serum glucose levels in preclinical studies. GSK8062 is valuable for research applications related to metabolic disorders and the therapeutic exploration of liver diseases. -
FXR Agonist
2-Oxokolavenol is a selective agonist of the farnesoid X receptor (FXR), demonstrating an EC50 of approximately 3.7 μM. This compound mitigates acetaminophen-induced hepatocyte damage through an FXR-dependent mechanism, facilitating the recruitment of co-activators and enhancing FXR transcriptional activity. Derived from the plant Aglaia spectabilis, 2-Oxokolavenol is valuable for research on liver diseases and the underlying mechanisms of FXR signaling. -
FXR Agonist
FXR agonist 14 is a selective, orally bioavailable agonist of the farnesoid X receptor (FXR), exhibiting an EC50 of 0.67 nM. This compound demonstrates significant biological activity by alleviating pathological features associated with metabolic syndrome in high-fat and high-sugar diet-induced MASH mice. Additionally, FXR agonist 14 plays a crucial role in exerting protective effects against anti-cholestatic liver disease, making it valuable for research in liver and metabolic disorders. -
FXR Agonist
Fargesone A is a selective agonist of the farnesoid X receptor (FXR). It demonstrates significant anti-inflammatory activity, making it a valuable tool for research in metabolic diseases and inflammatory conditions. This compound is ideal for studies investigating FXR's role in regulating lipid metabolism and inflammation. -
FXR Agonist
FXR Agonist 11 is a selective agonist of the farnesoid X receptor (FXR) with an EC50 of 1.2 μM and a maximum biological effect of 73.7%. This compound significantly elevates glutathione (GSH) levels in liver tissues, making it a valuable tool for investigating mechanisms of drug-induced liver injury and related hepatic disorders. Research applications include studies of metabolic regulation, liver protection, and the modulation of hepatic stress responses. -
FXR Agonist
PX20350 is an FXR (Farnesoid X receptor) agonist, exhibiting EC50 values of 83 nM and 10 nM for mouse and human FXR, respectively. This compound significantly induces the expression of NDRG2 mRNA and demonstrates potent anti-tumor activity by inhibiting the growth and metastasis of liver tumor cells, specifically SK-GI-18. Additionally, PX20350 has been shown to possess anti-tumorigenic effects in orthotopic xenograft mouse models, making it valuable for investigating liver cancer biology and therapeutic strategies. -
FXR Agonist
(E)-GW 4064 is a potent agonist of the farnesoid X receptor (FXR), a nuclear receptor that plays a crucial role in lipid and glucose metabolism. This compound has demonstrated significant biological activity in regulating bile acid synthesis and glucose homeostasis, making it a valuable tool for investigating metabolic disorders. Research applications include studying the effects of FXR activation on metabolic pathways and exploring its potential therapeutic benefits in conditions such as obesity and diabetes. -
FXR Agonist
Fexarine is a potent, non-steroidal selective agonist of the farnesoid X receptor (FXR) with an EC50 of 38 nM. This compound plays a significant role in the regulation of cholesterol and bile acid metabolism. Fexarine is valuable for research applications focusing on metabolic disorders and diseases associated with dysregulated lipid homeostasis. -
CES2 inhibitor; FXR agonist;
FXR/CES2 modulator 1 is a dual modulator that functions as an FXR agonist and a CES2 inhibitor. This compound demonstrates significant potential in reducing the intestinal toxicity associated with irinotecan administration. Its unique mechanism of action makes it a valuable tool for research aimed at understanding FXR modulation and its implications in gastrointestinal safety during chemotherapy. -
FXR-LIFR Modulator
BAR-2227 is a modulator that targets the Farnesoid X Receptor (FXR) as an agonist and inhibits the leukemia inhibitory factor receptor (LIFR). This compound plays a significant role in the investigation of liver fibrosis and associated inflammatory responses. Researchers can utilize BAR-2227 to explore its therapeutic potential in liver diseases and further elucidate underlying mechanisms of fibrosis and inflammation. -
FXR Agonist
Nelumol A is a potent agonist of the farnesoid X receptor (FXR). It is known to regulate bile acid homeostasis, lipid metabolism, and inflammatory responses. Due to its role in metabolic processes, Nelumol A is employed in research studying metabolic disorders, liver diseases, and the pharmacological modulation of FXR pathways. -
FXR Agonist
FXR Agonist 16 is a potent FXR agonist with an EC50 of 2.2 μM, effectively activating FXR transcriptional activity. This compound upregulates small heterodimer partner (SHP) and bile salt export pump (BSEP) while downregulating cytochrome P450 7A1 (Cyp7a1), which contributes to its hepatoprotective properties. FXR Agonist 16 is valuable for research focused on liver injury, demonstrating a reduction in serum AST and ALT levels in models of free fatty acid-induced hepatocellular damage. -
FXR Agonist
FXR Agonist 15 is a potent and selective farnesoid X receptor (FXR) agonist with an EC50 of 0.76 μM. This compound shows high specificity, exhibiting minimal activation of other nuclear receptors such as LXRα/β, PXR, PPARα/β/γ, and THR-β, with EC50 values greater than 10 μM. FXR Agonist 15 demonstrates the ability to mitigate steatosis, lobular inflammation, hepatocyte ballooning, and liver fibrosis, making it a valuable tool for research into nonalcoholic steatohepatitis (NASH). -
FXR Agonist
Fexarene is a potent and selective nonsteroidal agonist of the Farnesoid X Receptor (FXR), exhibiting an EC50 of 36 nM. This compound plays a crucial role in the regulation of cholesterol and bile acid metabolism, making it valuable for research investigating metabolic disorders and liver function. Fexarene's ability to selectively activate FXR positions it as a significant tool for studying its downstream effects in various biological systems. -
Herbicide Safener
Benoxacor is a herbicide safener that primarily acts as a regulator of xenobiotic metabolism. It protects maize from metolachlor toxicity by inducing detoxifying enzymes, such as Glutathione S-transferase, while also activating nuclear receptors like FXR, PXR, and ERRα, and inhibiting aromatase. Research indicates that Benoxacor may exhibit subacute oral toxicity and has been associated with hepatotoxicity in animal models, leading to effects on organ weights and alterations in gut microbiota. This compound is relevant for studies on hepatic steatosis, infertility, breast cancer, and developmental toxicity. -
FXR Agonist
ST-1892 is a potent agonist of the farnesoid X receptor (FXR), exhibiting an EC50 value of 7.2 nM. This compound plays a crucial role in studying metabolic inflammation-related diseases and disorders. Its selective activation of FXR allows for exploration of therapeutic strategies targeting metabolic pathways and liver-related conditions. -
FXR Agonist
GSK2324 is a selective agonist of the farnesoid X receptor (FXR), demonstrating an EC50 of 120 nM. This compound is predominantly utilized in diabetes research, where it plays a pivotal role in the modulation of metabolic processes. Pharmacokinetic studies reveal half-life values of 84 minutes in mice, 170 minutes in rats, 110 minutes in beagle dogs, and 120 minutes in cynomolgus monkeys, indicating its potential for translational studies. -
FXR Activator
5β-Cholane is a potent activator of the farnesoid X receptor (FXR). It plays a critical role in regulating bile acid homeostasis and lipid metabolism, making it a valuable tool for investigating cholesterol and lipid-related disorders. Researchers can utilize 5β-Cholane to better understand the molecular mechanisms underlying metabolic diseases and to explore therapeutic interventions targeting FXR. -
FXR Partial Agonist
FXR agonist 9 is a selective partial agonist of the farnesoid X receptor (FXR) with an EC50 of 0.09 µM, exhibiting 75.13% maximum efficacy. This compound has demonstrated the ability to improve pathological features associated with metabolic dysfunction and steatohepatitis in mouse models induced by a high-fat diet and carbon tetrachloride. FXR agonist 9 is valuable for research into metabolic disorders and liver diseases. -
FXR Antagonist
FXR antagonist 3 is a selective antagonist of the farnesoid X receptor (FXR) with an IC50 of 0.89 μM. This compound exhibits notable activity in modulating intestinal FXR signaling pathways, making it valuable for research related to metabolic disease and bile acid regulation. It serves as a useful tool in studying the physiological roles of FXR in gastrointestinal disorders and potential therapeutic interventions. -
ER α-glucosidases Inhibitor
IHVR-11029 is a potent small molecule inhibitor of ER α-glucosidases, demonstrating an EC50 of 0.09 μM. This compound is primarily utilized in research for exploring glucosidase enzymatic activity and its implications in metabolic disorders. Its specificity and efficacy make it a valuable tool for studies investigating glycosylation processes and related pathways. -
α-glucosidase Inhibitor
CM-10-18 is a potent inhibitor of α-glucosidases I and II, demonstrating significant activity in vitro and in animal models. This compound also exhibits antiviral properties by inhibiting dengue virus (DENV) infection in cultured human cells, while effectively reducing peak viremia in mice. CM-10-18 is valuable for research applications related to glycosidase inhibition and viral pathogenesis. -
α-Glucosidase Inhibitor
α-Glucosidase-IN-5 is a potent α-glucosidase inhibitor, exhibiting an IC50 of 57.9 µM. This compound is valuable for studying the modulation of carbohydrate metabolism and has potential applications in diabetes mellitus research. By inhibiting α-glucosidase, α-Glucosidase-IN-5 may aid in the investigation of glycemic control and the development of therapeutic strategies for diabetes management. -
Herbicide
L-Phosphinothricin is a potent inhibitor of glutamine synthetase and functions as a non-selective herbicide. By competitively inhibiting this enzyme, it leads to the accumulation of toxic ammonium ions in both plants and bacteria, thereby disrupting the photosynthesis process. L-Phosphinothricin demonstrates effective herbicidal activity against a wide range of plant species, including both monocots and dicots. This compound is predominantly absorbed through plant leaves, exhibits minimal translocation, and is rapidly degraded by soil microorganisms, making it valuable for research in weed management across agricultural and non-crop environments. -
Herbicide Safener
Mefenpyr-diethyl is a pyrazoline-type herbicide safener that enhances lipid biosynthesis in cereal crops such as wheat. It effectively mitigates phytotoxic damage from herbicides, including fenoxaprop-p-ethyl and mesosulfuron-methyl, ensuring crop safety and improved lipid content. Notably, the mechanism of action does not involve the induction of glutathione S-transferase (GST) activity in wheat, making Mefenpyr-diethyl a valuable tool for research in plant protection and herbicide safening applications. -
Anticoagulant/Cancer Agent
Fucoidan is a biologically active polysaccharide that functions as an anticoagulant and exhibits antitumor properties. It effectively inhibits α-amylase and α-glucosidase, contributing to its potential applications in metabolic disorder research. Additionally, Fucoidan demonstrates antioxidant and antisteatotic activities, making it a valuable tool for studying various disease processes and therapeutic interventions. -
α-glucosidase Inhibitor
Gallacetophenone is a potent inhibitor of α-glucosidase, displaying an IC50 value of 408.6 μM. This compound demonstrates synergistic effects on mammalian α-glucosidase when combined with 1-Deoxynojirimycin at elevated concentrations. Gallacetophenone is valuable for research into metabolic disorders, particularly type 2 diabetes, by facilitating the understanding of carbohydrate metabolism and its implications in glycemic control. -
UDP-GalNAc Analog
UDP-GalNAz disodium is an analogue of UDP-GalNAc disodium, serving as a donor substrate for N-acetylgalactosaminyltransferases, which facilitate the transfer of GalNAc to various saccharide or peptide acceptors. This compound features an azide group, making it a valuable reagent for click chemistry applications. UDP-GalNAz disodium can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-bearing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions involving DBCO or BCN groups. It is useful in the study of glycosylation pathways and the synthesis of complex glycoproteins. -
Glycosidase
PNGase F is a glycosidase that facilitates the cleavage of internal glycosidic bonds within oligosaccharides. This enzyme effectively removes nearly all N-linked oligosaccharides from glycoproteins, making it a valuable tool in glycoanalytical workflows. Its capability to release N-glycans from glycoproteins enhances the analysis of protein glycosylation patterns in various research applications. -
β-glucosidase fluorogenic substrate
4-Methylumbelliferyl β-D-Glucopyranoside serves as a fluorogenic substrate specifically for β-glucosidase, facilitating the measurement of β-glucosidase activity in various biological assays. Upon enzymatic cleavage, it releases 4-methylumbelliferone, a highly fluorescent compound with an emission maximum between 445-454 nm. The excitation wavelength of 4-methylumbelliferone is influenced by pH, showing peaks at 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively, making it a valuable tool for studying enzyme kinetics and related research applications. -
α/β-Glucosidases Inhibitor
Castanospermine is a natural alkaloid primarily recognized for its role as an α/β-glucosidase inhibitor. This compound exhibits significant biological activities, including anti-inflammatory and antiviral properties, as well as the potential to impede metastatic progression in prostate cancer. Additionally, Castanospermine has applications as an immunosuppressant, proving useful in preventing transplant rejection. Its diverse functionalities make it a valuable tool in various areas of biochemical research. -
β-Hexosaminidase Inhibitor
M-31850 is a selective and competitive inhibitor of β-hexosaminidase, demonstrating IC50 values of 6.0 μM for human HexA and 3.1 μM for human HexB. This compound also inhibits β-N-acetyl-D-hexosaminidase (OfHex2) with a Ki of 2.5 μM. M-31850 is valuable for research applications focused on lysosomal storage disorders and other biological contexts where β-hexosaminidase activity is implicated. -
Hydrolytic Enzymatic Complex
Naringinase is a hydrolytic enzymatic complex that exhibits both α-L-rhamnosidase and β-D-glucosidase activities. This enzyme is widely distributed in nature and plays a crucial role in the biotransformation of glycosides as well as steroids and antibiotics. Naringinase is valuable in research applications involving the hydrolysis of glycosides, facilitating various biochemical studies and industrial processes. -
α-Glucosidase Substrate
4-Nitrophenyl α-D-glucopyranoside is a chromogenic substrate specifically designed for the measurement of α-glucosidase activity. Upon hydrolysis by α-glucosidase, this compound produces a yellow chromophore, allowing for quantitative assessment of enzyme activity. It is widely utilized in biochemical assays to study carbohydrate metabolism and investigate the role of α-glucosidase in various biological processes. -
GCase Substrate
PFB-FDGlu is a highly selective substrate for lysosomal Glucocerebrosidase (GCase), engineered to be metabolized into fluorescein upon GCase activity. This compound is cell permeable, facilitating its use in flow cytometry to measure GCase activity in living cells at the single-cell level. PFB-FDGlu serves as an essential tool for studying GCase function in various biological contexts and is particularly relevant in research related to lysosomal storage disorders. -
Sugar Donor
UDP-GlcNAz disodium is a sugar donor analogue of UDP-GlcNAc disodium, serving as a substrate for various N-acetylgalactosaminyltransferases that facilitate the transfer of GlcNAc to saccharide or peptide acceptors. In addition to its enzymatic applications, UDP-GlcNAz disodium is a valuable click chemistry reagent featuring an azide group, capable of participating in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. It also enables strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-functionalized partners, making it useful for bioconjugation and labeling studies. -
Glycosidic Lyase
Heparitin sulfate lyase, also known as Heparinase III, is a glycosidic lyase that specifically targets heparan sulfate and heparin. This enzyme plays a crucial role in the degradation of glycosaminoglycans and is valuable for studies on low-molecular-weight heparin production. Additionally, Heparitin sulfate lyase is involved in cancer research, providing insights into tumor biology and therapeutic strategies. -
Cysteine Cathepsins Probe
DCG04 is an activity-based probe targeting cysteine cathepsins, serving as a multivalent ligand for the mannose-6-phosphate receptor. This compound enables the selective labeling of various cysteine cathepsins in cell and tissue lysates, facilitating the study of their roles in physiological and pathological processes. DCG04 is useful for researchers investigating enzyme activity and potential therapeutic interventions involving cysteine cathepsins. -
Bifidogenic Factor
Xylotriose is a natural xylooligosaccharide that serves as a bifidogenic factor, promoting the growth of beneficial bifidobacteria in the gastrointestinal tract. Its prebiotic properties enhance gut health by selectively stimulating the proliferation of these microorganisms. Xylotriose is utilized in research applications focused on gut microbiota modulation and may contribute to the development of functional foods aimed at improving digestive health. -
α-L-arabinofuranosidase Substrate
1,4-b-D-Xylopentaose is a linear pentasaccharide comprised of five β-D-xylose units linked by 1,4-glycosidic bonds. This compound functions as a specific substrate for the enzyme barley α-L-arabinofuranosidase, facilitating the study of enzyme activity and carbohydrate metabolism. It is widely utilized in research applications focused on plant cell wall degradation and glycoside hydrolases. -
Glycoside Hydrolase
β-Glucosidase, almond is a glycoside hydrolase that functions as a critical enzyme in cellulose degradation. This enzyme plays a significant role in the hydrolysis of β-glucosidic bonds, facilitating the breakdown of cellulose in various environments, including soils. Its activity is pivotal for assessing soil quality and understanding carbon cycling in ecosystems. Researchers utilize β-Glucosidase for studies related to plant biology, soil microbiology, and environmental monitoring. -
Antioxidant Agent
2-(2-Phenylethyl)chromone is an antioxidant agent that targets free radicals, particularly through the scavenging of ABTS·+. This compound exhibits a range of biological activities, including anti-inflammatory, neuroprotective, anti-tumor, and α-glucosidase inhibitory effects. It is valuable for research applications in inflammation-related diseases, cancer studies, and neurodegenerative disorders. -
α-glucosidase I Inhibitor
Kojibiose is an α-glucosidase I inhibitor that functions as an orally active prebiotic disaccharide. It specifically inhibits the activity of α-glucosidase I, promoting the proliferation of beneficial gut bacteria such as Bifidobacterium and lactic acid bacteria. Additionally, kojibiose serves as a low-calorie sweetener that enhances iron absorption and exhibits antitoxic properties. In vivo studies demonstrate its ability to reduce hepatic expression of inflammatory markers, highlighting its potential applications in metabolic and gastrointestinal research. -
ColA Inhibitor
4',5-Dihydroxyflavone is a potent inhibitor of collagenase A (ColA), with an IC50 value of less than 1 μM. This flavonoid compound also shows inhibitory activity against α-glucosidase and soybean lipoxygenase-1, making it valuable in biochemical research. Its applications include studies focused on anti-toxicity and anti-diabetes, highlighting its potential therapeutic benefits in metabolic and inflammatory disorders.
