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Amylases

Amylase compounds include the starch-digesting enzyme, oligosaccharide substrates and glycosidase inhibitors. Alpha-amylases cleave internal α-1,4-glycosidic bonds of starch and glycogen and release maltose and short dextrins. Salivary and pancreatic amylases start starch digestion, and the structure of human salivary amylase was solved at 1.6 Å resolution in 1996. In 2007, copy number of the salivary amylase gene (AMY1) was found to be higher in populations with high-starch diets. The list holds the enzyme itself as Amylase and the defined substrate maltotetraose for activity assays. Deoxynojirimycin, an iminosugar that inhibits glucosidases I and II, represents the glycosidase inhibitors. Other entries are mixed, such as proglumide sodium salt and the stilbene gnetol.

1 Item

  • Lotusine hydroxide
    Cat. No.
    A69481
    CAS No.
    3721-76-4

    Lotusine hydroxide

    Lotusine hydroxide is an alkaloid that functions as a signaling pathway modulator and enzyme inhibitor. It exhibits notable inhibitory activity against α-amylase and α-glucosidase, with IC50 values of 30.60 μg/mL and 36.15 μg/mL, respectively. Lotusine hydroxide effectively inhibits the EGFR-Akt-ERK signaling pathway by decreasing phosphorylated levels of EGFR, Akt, and ERK, leading to apoptosis, G0/G1 cell cycle arrest, and reduced cancer cell proliferation. Additionally, it enhances antioxidant enzyme activities and is relevant for research on non-small cell lung cancer, type 2 diabetes, and autism spectrum disorder.

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    5 mg
    $170.00
    10 mg
    $295.00
    All 2 sizes

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