- Cat. No.
- A12595
BIO-32546
BIO-32546 is a novel modulator of the activity of the autotaxin (ATX) enzyme
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Autotaxin inhibitors act on the secreted enzyme that produces the lipid mediator lysophosphatidic acid (LPA). Autotaxin, also called ectonucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2), is a lysophospholipase D that releases LPA from lysophosphatidylcholine. LPA signals through G protein-coupled receptors to regulate cell proliferation, migration and survival. Autotaxin has therefore been studied in cancer cell motility, fibrosis and inflammation. In mouse models, autotaxin expression in the lung contributes to the development of pulmonary fibrosis. Compounds in this category include PF-8380, HA130, PAT-505 and Autotaxin-IN-1, for studies of the autotaxin-LPA axis.
BIO-32546 is a novel modulator of the activity of the autotaxin (ATX) enzyme