Carboxylesterase (CES)

Cat. No.

A43764

CAS No.

2413816-64-3

CEMT

CEMT is a selective substrate for carboxylesterases, functioning as a ratiometric two-photon fluorescent reporter probe. Upon hydrolysis by carboxylesterases, CEMT generates HMT, which facilitates mitochondrial pH sensing through ratiometric fluorescence changes in response to pH fluctuations. This compound specifically targets and covalently binds to mitochondria, minimizing leakage during acidification, thereby enabling in situ imaging of mitochondrial dynamics and pH variations within biological systems.

Cat. No.

A45350

CAS No.

500883-59-0

DDAO phosphate diammonium

DDAO phosphate diammonium is a fluorescent phosphatase substrate that serves as a sensitive probe for enzyme activity. With tunable excitation wavelengths ranging from 600 to 650 nm and a long emission wavelength of 656 nm, it facilitates the detection of various enzymes including β-galactosidase, sulfatase, protein phosphatase 2A, carboxylesterase 2, human albumin, and esterase. This reagent is ideal for applications in enzymology and biochemistry research, enabling real-time monitoring of enzyme activities in different biological systems.

Cat. No.

A69569

CAS No.

139-45-7

Tripropionin

Synonyms: Glycerol tripropionate

Tripropionin, a triglyceride, acts as a substrate for carrot carboxylesterase. It exhibits key biological activity as a hydrolyzable ester, making it suitable for applications in lipid nanoemulsion formulation. This compound can effectively serve as the oil phase for creating high-performance lipid nanoemulsion droplets, facilitating the encapsulation, stable storage, and controlled release of bioactive compounds such as Combretastatin A4.

Cat. No.

A69588

CAS No.

6280-99-5

Dibutyl malate

Synonyms: DL-Malic acid dibutyl ester

Dibutyl malate serves as a substrate for carboxylesterase, an enzyme critical in the hydrolysis of ester bonds. This compound is particularly useful in biochemical studies investigating enzymatic activity and substrate specificity. It is also applicable in drug metabolism and pharmacokinetic research, aiding in the understanding of ester-containing pharmaceuticals.

Cat. No.

A71170

CAS No.

9016-18-6

Esterase, pig liver

Synonyms: CESs

Esterase, pig liver is a type of carboxylesterase known for its role in the hydrolysis of a wide range of endogenous and exogenous substrates. This enzyme catalyzes the breakdown of carboxylic acid esters into corresponding alcohols and carboxylic acids, facilitating important biochemical reactions. Its extensive distribution in mammalian liver makes it a valuable tool in biochemical research, particularly for studies involving ester metabolism and enzyme kinetics.

Cat. No.

A88597

CAS No.

4346-15-0

3-Indoxyl butyrate

3-Indoxyl butyrate serves as a chromogenic substrate for carboxylesterase (CES), leading to the generation of a blue precipitate upon enzymatic cleavage. This reaction makes it a valuable tool for detecting and quantifying CES activity in biological samples. Its sensitivity and specificity enhance research applications in enzyme kinetics and drug metabolism studies.