FAAH

Cat. No.

A59238

CAS No.

2876918-67-9

CB2R/FAAH modulator-3

CB2R/FAAH modulator-3 is a dual-targeting compound that functions as an agonist of the cannabinoid receptor type 2 (CB2R) and an inhibitor of fatty acid amide hydrolase (FAAH). It exhibits Ki values of 20.1 nM for CB2R and 67.6 nM for CB1R, with an IC50 of 3.4 μM for FAAH. This modulator is valuable for research into cancer biology, inflammatory processes associated with neurodegenerative diseases, and potential therapeutic approaches for COVID-19.

Cat. No.

A59324

CAS No.

928892-60-8

CB2R/FAAH modulator-1

CB2R/FAAH modulator-1 is a potent full agonist of the cannabinoid type 2 receptor (CB2R), exhibiting a binding affinity with a Ki of 14.8 nM for CB2R and 241.3 nM for CB1R. This compound also serves as an inhibitor of fatty acid amide hydrolase (FAAH), demonstrating an IC50 of 4 μM. CB2R/FAAH modulator-1 is effective in modulating cytokine production by decreasing pro-inflammatory cytokines while enhancing anti-inflammatory cytokine levels, making it valuable for research in inflammation and pain modulation.

Cat. No.

A74629

CAS No.

2128258-47-7

Sob-AM2

Sob-AM2 is a high-affinity substrate for fatty acid amide hydrolase (FAAH), exhibiting a Km of 1.3 μM and demonstrating effective blood-brain barrier permeability. This compound facilitates elevated delivery of Sobetirome to the central nervous system while minimizing peripheral exposure, thus activating central thyroid hormone receptor β (TRβ). Additionally, Sob-AM2 has been shown to protect against myelin and axon degeneration in models of experimental autoimmune encephalomyelitis (EAE), making it a valuable tool for investigating neuroprotective mechanisms and central nervous system disorders.

Cat. No.

A74639

CAS No.

1942003-30-6

N-Nervonoyl taurine

Synonyms: (Z)-2-tetracos-15-enamidoethanesulfonic acid

N-Nervonoyl taurine, a fatty acid-taurine conjugate derived from nervonic acid, serves as a substrate for fatty acid amide hydrolase (FAAH). This compound plays a significant role in lipid metabolism and inflammation regulation. It is used in research applications focused on understanding FAAH's enzymatic activity and its implications in various physiological and pathological processes.

Cat. No.

A74658

CAS No.

693265-89-3

MDPD

MDPD is an activator of Arabidopsis fatty acid amide hydrolase (AtFAAH), promoting increased enzymatic activity of this important regulatory enzyme. This compound is utilized in research applications focused on lipid metabolism and amide hydrolysis pathways, contributing to the understanding of fatty acid signaling processes in plant biology. MDPD's ability to enhance AtFAAH activity makes it a valuable tool for studies investigating the physiological roles of fatty acid amides in Arabidopsis.

Cat. No.

A74666

CAS No.

85146-53-8

Arachidonamide

Synonyms: Arachidonoyl amine; Arachidonic acid amide

Arachidonamide is a substrate for fatty acid amide hydrolase (FAAH), an important enzyme in the endocannabinoid system. This compound is utilized in research to investigate the biochemical pathways involving anandamide metabolism and its implications in various physiological processes. Arachidonamide can serve as a valuable tool in studies focused on pain relief, neuroprotection, and inflammation.

Cat. No.

A74668

CAS No.

1175954-87-6

Arachidonoyl m-nitroaniline

Arachidonoyl m-nitroaniline is a substrate for fatty acid amide hydrolase (FAAH), facilitating the measurement of FAAH activity in biochemical assays. This compound serves as a reliable tool for researchers investigating the metabolism of fatty acid amides and the role of FAAH in various biological processes. Its utilization aids in elucidating the enzymatic mechanisms and potential therapeutic targets related to endocannabinoid signaling and pain modulation.

Cat. No.

A92803

CAS No.

72298-61-4

Decanoyl m-Nitroaniline

Synonyms: DemNA

Decanoyl m-Nitroaniline is a substrate specifically designed for the assessment of fatty acid amide hydrolase (FAAH) activity. Its unique structure allows for the efficient measurement of FAAH function through absorbance detection at 410 nm. This compound is valuable for research applications focused on endocannabinoid modulation and lipid signaling pathways.