Search by product name, CAS, target or catalog number. Press Down Arrow to reach product suggestions, Tab to move between links, and Escape to close suggestions.
Glucokinase activators act on hexokinase IV, the glucose sensor of pancreatic beta cells and the liver. Glucokinase (GK) phosphorylates glucose to glucose-6-phosphate with low affinity and without inhibition by its product. Its activity therefore rises and falls with blood glucose over the physiological range. A 1995 study of knockout mice showed that beta-cell glucokinase is required to maintain glucose homeostasis. In 2003 Ro 28-1675 was described as an allosteric activator that binds outside the active site and increases glucose affinity. Later activators in the catalogue include piragliatin, MK-0941 and globalagliatin. PF-04991532 is a hepatoselective activator used to separate liver effects from those in islets.
PF-04279405 is a potent glucokinase (GK) agonist with an EC50 of 23 nM. Glucokinase is crucial for glucose metabolism, facilitating the conversion of glucose to glucose-6-phosphate and contributing to glucose homeostasis. This compound is valuable for research applications targeting type 2 diabetes, offering insights into therapeutic mechanisms and metabolic regulation.
