- Cat. No.
- A17030
LTI-291
LTI-291 is a glucocerebrosidase (Gcase) activator for treatment of Parkinson's disease (PD).
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- Cat. No.
- A22122
ML198
ML198 is a novel activator and non-inhibitory chaperone of glucocerebrosidase.
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- Cat. No.
- A69481
Lotusine hydroxide
Lotusine hydroxide is an alkaloid that functions as a signaling pathway modulator and enzyme inhibitor. It exhibits notable inhibitory activity against α-amylase and α-glucosidase, with IC50 values of 30.60 μg/mL and 36.15 μg/mL, respectively. Lotusine hydroxide effectively inhibits the EGFR-Akt-ERK signaling pathway by decreasing phosphorylated levels of EGFR, Akt, and ERK, leading to apoptosis, G0/G1 cell cycle arrest, and reduced cancer cell proliferation. Additionally, it enhances antioxidant enzyme activities and is relevant for research on non-small cell lung cancer, type 2 diabetes, and autism spectrum disorder.
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- Cat. No.
- A75100
GCase modulator-1
GCase modulator-1 is a Quinazoline derivative targeting GCase (Glucosidase) with an AC50 of 2.23 μM. This compound serves as a potent modulator, influencing GCase activity and its associated metabolic pathways. It is primarily utilized in research focused on lysosomal storage disorders and potential therapeutic strategies for related conditions.
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- Cat. No.
- A75182
5-C-phenethyl-DNJ hydrochloride
5-C-phenethyl-DNJ hydrochloride is a potent activator of acid α-glucosidase (GAA). It enhances GAA activity across multiple tissues, notably in the diaphragm, making it a valuable tool for research into metabolic disorders, including Pompe disease. This compound provides insights into therapeutic strategies aimed at modulating GAA activity for the treatment of glycemic imbalances.
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