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Glucosidase

Glucosidase inhibitors block enzymes that cleave glucose units from oligosaccharides, disaccharides and glycoproteins. Intestinal α-glucosidases break down dietary carbohydrates, so their inhibitors are used to study postprandial glucose uptake. Acarbose, a pseudo-oligosaccharide, and miglitol, an iminosugar, are standard inhibitors of these enzymes. In the endoplasmic reticulum, glucosidases I and II trim glucose residues from newly attached N-linked glycans. Trimming and later reglucosylation control glycoprotein binding to the chaperone calnexin, as reported in 1995. Deoxynojirimycin and celgosivir inhibit these processing glucosidases and are used in glycoprotein folding and virology research. Miglustat hydrochloride, an N-alkylated iminosugar, also inhibits glucosylceramide synthase in glycosphingolipid research.

Cat. No.

A17030

CAS No.

1919820-28-2

LTI-291

LTI-291 is a glucocerebrosidase (Gcase) activator for treatment of Parkinson's disease (PD).

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1 mg

$35.00

5 mg

$90.00

All 8 sizes
Cat. No.

A22122

CAS No.

1380716-06-2

ML198

ML198 is a novel activator and non-inhibitory chaperone of glucocerebrosidase.

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2 mg

$35.00

5 mg

$80.00

All 7 sizes
Cat. No.

A75182

CAS No.

2763641-30-9

5-C-phenethyl-DNJ hydrochloride

5-C-phenethyl-DNJ hydrochloride is a potent activator of acid α-glucosidase (GAA). It enhances GAA activity across multiple tissues, notably in the diaphragm, making it a valuable tool for research into metabolic disorders, including Pompe disease. This compound provides insights into therapeutic strategies aimed at modulating GAA activity for the treatment of glycemic imbalances.

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Out of stock
All 3 sizes

Glucosidase

LTI-291

ML198

5-C-phenethyl-DNJ hydrochloride