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Glucosidase

Glucosidase inhibitors block enzymes that cleave glucose units from oligosaccharides, disaccharides and glycoproteins. Intestinal α-glucosidases break down dietary carbohydrates, so their inhibitors are used to study postprandial glucose uptake. Acarbose, a pseudo-oligosaccharide, and miglitol, an iminosugar, are standard inhibitors of these enzymes. In the endoplasmic reticulum, glucosidases I and II trim glucose residues from newly attached N-linked glycans. Trimming and later reglucosylation control glycoprotein binding to the chaperone calnexin, as reported in 1995. Deoxynojirimycin and celgosivir inhibit these processing glucosidases and are used in glycoprotein folding and virology research. Miglustat hydrochloride, an N-alkylated iminosugar, also inhibits glucosylceramide synthase in glycosphingolipid research.

2 Items

  • Oroxin A
    Cat. No.
    A15695
    CAS No.
    57396-78-8

    Oroxin A

    Oroxin A is a partial agonist of the peroxisome proliferator-activated receptor gamma (PPARγ). It enhances PPARγ transcriptional activity through binding to the PPARγ ligand-binding domain. Additionally, Oroxin A demonstrates inhibitory effects on α-glucosidase and possesses antioxidant properties. Its anti-breast cancer potential is attributed to the induction of endoplasmic reticulum stress-mediated cellular senescence, making it a valuable tool for research in metabolic and cancer biology.

    In stock View Details
    1 mg
    $30.00
    5 mg
    $65.00
    All 7 sizes
  • Endoglycoceramidase II (EGCase II)
    Cat. No.
    A72240
    CAS No.
    2763216-34-6

    Endoglycoceramidase II (EGCase II)

    Endoglycoceramidase II (EGCase II) is an endo-β-glucosidase that specifically cleaves β-glycosidic linkages between glucose and ceramide in glycosphingolipids. This enzyme catalyzes the hydrolysis of these linkages, thereby releasing intact glycans from ceramides. EGCase II is instrumental in glycosphingolipid research, facilitating the structural analysis and functional studies of glycoconjugates in various biological contexts. It serves as a valuable tool in understanding glycan-mediated cellular processes and their implications in health and disease.

    In stock View Details
    1 mg
    $560.00
    All 1 sizes

2 Items

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