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Glucosidase

Glucosidase inhibitors block enzymes that cleave glucose units from oligosaccharides, disaccharides and glycoproteins. Intestinal α-glucosidases break down dietary carbohydrates, so their inhibitors are used to study postprandial glucose uptake. Acarbose, a pseudo-oligosaccharide, and miglitol, an iminosugar, are standard inhibitors of these enzymes. In the endoplasmic reticulum, glucosidases I and II trim glucose residues from newly attached N-linked glycans. Trimming and later reglucosylation control glycoprotein binding to the chaperone calnexin, as reported in 1995. Deoxynojirimycin and celgosivir inhibit these processing glucosidases and are used in glycoprotein folding and virology research. Miglustat hydrochloride, an N-alkylated iminosugar, also inhibits glucosylceramide synthase in glycosphingolipid research.

4 Items

  • Oroxin A
    Cat. No.
    A15695
    CAS No.
    57396-78-8

    Oroxin A

    Oroxin A is a partial agonist of the peroxisome proliferator-activated receptor gamma (PPARγ). It enhances PPARγ transcriptional activity through binding to the PPARγ ligand-binding domain. Additionally, Oroxin A demonstrates inhibitory effects on α-glucosidase and possesses antioxidant properties. Its anti-breast cancer potential is attributed to the induction of endoplasmic reticulum stress-mediated cellular senescence, making it a valuable tool for research in metabolic and cancer biology.

    In stock View Details
    1 mg
    $30.00
    5 mg
    $65.00
    All 7 sizes
  • Lotusine hydroxide
    Cat. No.
    A69481
    CAS No.
    3721-76-4

    Lotusine hydroxide

    Lotusine hydroxide is an alkaloid that functions as a signaling pathway modulator and enzyme inhibitor. It exhibits notable inhibitory activity against α-amylase and α-glucosidase, with IC50 values of 30.60 μg/mL and 36.15 μg/mL, respectively. Lotusine hydroxide effectively inhibits the EGFR-Akt-ERK signaling pathway by decreasing phosphorylated levels of EGFR, Akt, and ERK, leading to apoptosis, G0/G1 cell cycle arrest, and reduced cancer cell proliferation. Additionally, it enhances antioxidant enzyme activities and is relevant for research on non-small cell lung cancer, type 2 diabetes, and autism spectrum disorder.

    In stock View Details
    5 mg
    $170.00
    10 mg
    $295.00
    All 2 sizes
  • Endoglycoceramidase II (EGCase II)
    Cat. No.
    A72240
    CAS No.
    2763216-34-6

    Endoglycoceramidase II (EGCase II)

    Endoglycoceramidase II (EGCase II) is an endo-β-glucosidase that specifically cleaves β-glycosidic linkages between glucose and ceramide in glycosphingolipids. This enzyme catalyzes the hydrolysis of these linkages, thereby releasing intact glycans from ceramides. EGCase II is instrumental in glycosphingolipid research, facilitating the structural analysis and functional studies of glycoconjugates in various biological contexts. It serves as a valuable tool in understanding glycan-mediated cellular processes and their implications in health and disease.

    In stock View Details
    1 mg
    $560.00
    All 1 sizes
  • GCase modulator-1
    Cat. No.
    A75100
    CAS No.
    796079-91-9

    GCase modulator-1

    GCase modulator-1 is a Quinazoline derivative targeting GCase (Glucosidase) with an AC50 of 2.23 μM. This compound serves as a potent modulator, influencing GCase activity and its associated metabolic pathways. It is primarily utilized in research focused on lysosomal storage disorders and potential therapeutic strategies for related conditions.

    In stock View Details
    5 mg
    $35.00
    10 mg
    $55.00
    All 4 sizes

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