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Catalog No.
Product Name
Application
Product Information
Citations
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Glucosidase Inhibitor
N-5-Carboxypentyl-1-deoxynojirimycin is an alpha-glucosidase inhibitor with significant potential in glycosidase research. This compound is utilized for its ability to selectively inhibit glucosidase enzymes, making it valuable in studies exploring carbohydrate metabolism and related pathways. Additionally, it serves as a precursor for the preparation of affinity matrices, facilitating the binding of target proteins to resins for purification and analysis. -
α-Glucosidase Inhibitor
Sativanone is a potent α-glucosidase inhibitor, exhibiting an EC50 value of 0.357 mg/mL for rat α-glucosidase. Isolated from Dalbergia tonkinensis, this compound demonstrates antibacterial activity against Ralstonia solanacearum. Additionally, Sativanone exhibits anti-senescent and antioxidant properties, making it a valuable reagent for research in metabolic disorders, bacterial infections, and oxidative stress-related studies. -
Glycosidase Inhibitor
Panosialin D is a glycosidase inhibitor that selectively targets α,β-glucosidase and mannose glycosidase. This compound does not exhibit activity against the influenza virus; however, it demonstrates weak antimicrobial properties. It serves as a valuable reagent for research focused on glycosidase-related pathways and antimicrobial studies. -
α-glucosidase Inhibitor
Enhydrin is a naturally occurring α-glucosidase inhibitor derived from the leaves of Smallanthus sonchifolius. It demonstrates potent inhibitory activity with an IC50 value of 34.17 μg/mL, making it relevant for the management of postprandial hyperglycemia. Research indicates that Enhydrin can effectively reduce blood glucose levels in diabetic rat models, supporting its potential application in diabetes research and therapy development. -
α-Glucosidase Inhibitor
Cembrene A is an α-glucosidase inhibitor derived from the soft coral S. crassa, demonstrating an IC50 value of 30.31 μM. This compound exhibits minimal cytotoxicity in human normal hepatocyte (LO2) cells, with an IC50 greater than 100 μM. Cembrene A is a valuable reagent for research focused on diabetes and the modulation of carbohydrate metabolism. -
Alpha-Glucosidase Inhibitor
Acarbose sulfate is a potent alpha-glucosidase inhibitor, exhibiting an IC50 of 11 nM. This antihyperglycemic agent is utilized in research to investigate its potential to enhance the hypoglycemic effects of sulfonylureas or insulin. Its mechanism of action involves the modulation of carbohydrate absorption, making it valuable in studies related to diabetes and blood glucose regulation. -
α-Glucosidase Inhibitor
Arisanschinin D is an inhibitor of α-Glucosidase, a critical enzyme involved in carbohydrate metabolism. This compound can be isolated from Schisandra arisanensis and is of particular interest for research in diabetes management and metabolic disorders. Its ability to modulate enzyme activity makes it a valuable tool for studying the effects of carbohydrate absorption and glucose homeostasis. -
Glycosidase Inhibitor
Cefetrizole is an α-Glucosidase inhibitor that exhibits potent enzymatic activity, with an IC50 of 2.1 μM and a Ki value of 0.578 μM. This compound is primarily utilized in research applications focused on carbohydrate metabolism and associated disorders. Its ability to inhibit glycosidase activity makes it a valuable tool for investigating enzymatic pathways and developing therapeutic strategies. -
Heme Oxygenase Inhibitor
Zn(II) Mesoporphyrin IX is a potent inhibitor of heme oxygenase, particularly affecting the enzymatic activity in bone marrow. This compound demonstrates significant biological activity by inhibiting the growth of erythroid and myeloid progenitor cells, as well as blocking rhG-CSF-induced mobilization of these cells into peripheral blood. Zn(II) Mesoporphyrin IX is suitable for research applications involving hematopoietic regulation. However, its photochemical properties and potential toxicity to hematopoietic growth warrant careful consideration in experimental designs. -
HO-1 Inhibitor
Heme Oxygenase-1-IN-3 is a selective inhibitor of heme oxygenase-1 (HO-1), characterized by a dissociation constant (Kd) of 141 nM. This compound is valuable for investigating the role of HO-1 in cancer progression and neurodegenerative diseases. Its specificity makes it an essential tool for researchers studying the mechanism of HO-1 and its implications in various pathological conditions. -
CYP2C9/CYP3A4 Inhibitor
AR-C141990 functions as a dual inhibitor of CYP2C9 and CYP3A4, exhibiting IC50 values of 16 μM for both enzymes. This compound is recognized for its significant bioactivity, particularly as it inhibits the monocarboxylate transporter MCT1 with a Ki value of 4.8 nM. AR-C141990 is employed in research applications focused on drug metabolism and pharmacokinetics, as well as studies investigating interactions between drugs and metabolic pathways. -
11β-HSD2 Inhibitor
18β-Glycyrrhetyl-3-O-sulfate is a potent inhibitor of the enzyme 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2), exhibiting an IC50 value of 0.10 µM in rat kidney microsomes. As the principal metabolite of Glycyrrhetinic acid, this compound serves as a substrate for organic anion transporters OAT1 and OAT3. Its anti-inflammatory properties make it a valuable tool for studying pseudohyperaldosteronism and related conditions in biochemical and pharmacological research. -
Acetylcholinesterase Inhibitor, Butyrylcholinesterase Inhibitor, Carbonic Anhydrase I/II Inhibitor, α-Glycosidase Inhibitor
Vescalagin is a hexahydroxyphenol that acts as an inhibitor of acetylcholinesterase and butyrylcholinesterase, as well as carbonic anhydrases I and II, and α-glycosidase. It demonstrates potent inhibitory activity with Ki values of 5.87 nM for AChE, 3.89 nM for BChE, 11.75 nM for hCA I, 16.23 nM for hCA II, and 16.08 nM for α-glycosidase. Vescalagin exhibits non-competitive inhibition for hCA I, hCA II, and α-glycosidase, while also reducing hyperglycemia and hypertriglyceridemia in dietary models. Additionally, it possesses anti-inflammatory and antioxidant activities, making it a valuable compound for research in diabetes and metabolic disorders. -
IDO1 Inhibitor
IDO1-IN-19 is a selective inhibitor of Indoleamine 2,3-dioxygenase 1 (IDO1), exhibiting an IC50 value of 8.64 μM for CYP2C9. In addition, it modulates cardiac ion channels with IC50 values of 12 μM for IKr, 40 μM for INa, and 8.3 μM for ICa. This compound is valuable for investigating the mechanisms of cancer biology and has potential applications in cancer therapeutics. -
5-lipoxygenase Inhibitor
ETH-615 is a potent inhibitor of 5-lipoxygenase, an enzyme involved in the biosynthesis of leukotrienes, which play a significant role in inflammatory processes. This compound demonstrates key biological activity in reducing inflammation and may have implications for research into cardiovascular diseases and other inflammatory disorders. Its efficacy in modulating leukotriene synthesis makes ETH-615 valuable for studies aimed at understanding the underlying mechanisms of cardiovascular pathology. -
15-LOX-1 Inhibitor
ML351 is a potent inhibitor of 15-lipoxygenase-1 (15-LOX-1) with an IC50 of 200 nM, demonstrating exceptional selectivity with over 250-fold preference compared to related isozymes such as 5-LOX, platelet 12-LOX, and 15-LOX-2, as well as ovine COX-1 and human COX-2. This compound has shown significant biological activity in preventing dysglycemia and reducing β-cell oxidative stress in a nonobese diabetic mouse model of Type 1 Diabetes. ML351 is useful in studying the role of 15-LOX-1 in metabolic diseases and may have implications for therapeutic strategies targeting oxidative stress in diabetes. -
Lipoxygenase Inhibitor
Masoprocol, a lipoxygenase inhibitor, demonstrates significant antihyperglycemic activity by effectively lowering glucose levels and hepatic triglycerides in vivo. This compound is particularly valuable for researching type II diabetes mechanisms and potential therapeutic strategies. Its ability to modulate metabolic pathways positions Masoprocol as an important reagent in diabetes research. -
15-LOX-1 Inhibitor
15-LOX-1 inhibitor 1 is a selective inhibitor of 15-lipoxygenase-1 (15-LOX-1) with an IC50 value of 0.19 μM. This compound demonstrates protective effects on macrophages against cytotoxicity induced by lipopolysaccharide, while also inhibiting nitric oxide formation and lipid peroxidation. With its ability to modulate inflammatory pathways, 15-LOX-1 inhibitor 1 is valuable for research applications focused on inflammation and oxidative stress. -
5-Lipoxygenase Inhibitor
Stearidonic acid (6Z,9Z,12Z,15Z-Octadecatetraenoic acid) is a polyunsaturated fatty acid that acts as a potent inhibitor of 5-lipoxygenase, thereby reducing the synthesis of leukotrienes and 5-HETE. This compound has been shown to enhance the levels of eicosapentaenoic acid (EPA) in red blood cells. Stearidonic acid is employed in research focusing on metabolic diseases and inflammatory pathways, making it a valuable tool for studying lipid metabolism and related disorders. -
5/12/15-Lipoxygenase Inhibitor
2-TEDC is a potent inhibitor of 5-, 12-, and 15-lipoxygenase, demonstrating IC50 values of 0.09 μM, 0.013 μM, and 0.5 μM, respectively. This compound is valuable in the study of lipoxygenase pathways and their role in inflammatory processes. 2-TEDC is particularly relevant for research focused on atherosclerosis, providing insights into its mechanistic actions and potential therapeutic interventions. -
15-LOX-1 Inhibitor
ThioLox is a competitive inhibitor of 15-lipoxygenase-1 (15-LOX-1) with a Ki value of 3.30 μM. This compound exhibits significant anti-inflammatory and neuroprotective effects, making it a valuable tool in research focused on inflammation-related disorders and neurodegenerative diseases. Its ability to modulate 15-LOX-1 activity facilitates the exploration of lipid metabolism and its impact on cellular health. -
12/15-Lipoxygenases Inhibitor
Cinnamyl-3,4-dihydroxy-α-cyanocinnamate is an effective inhibitor of 12/15-Lipoxygenases (LO). This compound demonstrates significant anti-inflammatory properties, making it a valuable tool for investigating the role of lipoxygenases in various diseases, including type 1 diabetes mellitus. Its specificity towards these enzymes provides researchers with a robust agent for studying inflammatory pathways and potential therapeutic interventions. -
5-LOX Inhibitor
5-LOX-IN-2 is a selective inhibitor of 5-lipoxygenase (5-LOX), exhibiting an IC50 value of 0.33 μM. This compound effectively inhibits 5-LOX activity in a dose-dependent manner and has demonstrated the ability to reduce cell viability in renal cancer cells while promoting apoptosis. Its potential applications in cancer research make it a valuable tool for studying the role of 5-LOX in tumor biology. -
Tyrosinase/LOX Inhibitor
3-Hydroxycoumarin is a potent inhibitor of tyrosinase and lipoxygenase, exhibiting an IC50 of 26 μM against recombinant human tyrosinase and a Ki of 3.39 μM. It also demonstrates effective inhibition of lipoxygenase with an IC50 of 9.5 μM. Additionally, 3-Hydroxycoumarin displays significant DPPH free radical scavenging activity (IC50 = 31.2 μM) and offers photoprotective benefits for sea urchin zygotes and embryos, making it a valuable reagent for research in enzymatic inhibition and oxidative stress studies. -
Lipoxygenase Inhibitor
5,8,11-Eicosatriynoic acid is a potent lipoxygenase inhibitor that effectively disrupts the biosynthesis of leukotriene C4 (LTC4) in mast cell tumor cells. This compound is useful for researchers investigating the role of leukotrienes in inflammation and allergic responses. Additionally, it can be employed in studies focused on the modulation of lipoxygenase pathways in various biological systems. -
5-LOX Inhibitor
Picrinine, a 5-lipoxygenase (5-LOX) inhibitor, is an alkaloid derived from the leaves of Alstonia scholaris. This compound demonstrates significant anti-inflammatory effects by targeting and inhibiting the activity of the 5-LOX enzyme. Picrinine is useful for research applications related to inflammation and may provide insights into therapeutic strategies for inflammatory diseases. -
Lipoxygenase Inhibitor
Lonapalene is a selective inhibitor of 5-lipoxygenase (5-LO). It exhibits significant anti-inflammatory activity by blocking the production of leukotrienes, which are mediators involved in various inflammatory conditions. This compound is primarily utilized in research aimed at understanding and exploring therapeutic interventions for diseases associated with leukotriene signaling. -
LOX-2 Inhibitor
MLS000545091 is a potent and selective inhibitor of lipoxygenase-2 (LOX-2), demonstrating an IC50 value of 2.6 μM for the human enzyme h15-LOX-2. This compound is valuable for research into inflammatory processes and related diseases, facilitating investigations into the role of LOX-2 in various biological pathways. Its specificity makes it a useful tool for exploring therapeutic strategies targeting LOX-2-related conditions. -
5-Lipoxygenase Inhibitor
5-LOX-IN-4 is a selective inhibitor of 5-Lipoxygenase (5-LOX), a key enzyme involved in the biosynthesis of leukotrienes. This compound plays a significant role in modulating inflammatory responses and is valuable for research applications targeting asthma, allergies, and other inflammatory diseases. Its inhibition of 5-LOX may contribute to understanding leukotriene-related pathways and exploring potential therapeutic strategies. -
Lipoxygenase Inhibitor
Setileuton is a selective inhibitor of 5-lipoxygenase, effectively modulating the oxidation of arachidonic acid. It demonstrates significant inhibition of leukotriene B4 (LTB4) production in calcium ionophore-stimulated human whole blood, with IC50 values of 3.9 nM and 52 nM, respectively. This compound is valuable for research applications focused on inflammatory pathways and leukotriene-mediated processes. -
LOX-1 Inhibitor
KKII5 is a selective inhibitor of Lipoxygenase-1 (LOX-1) with an IC50 value of 19 μM. It effectively reduces lipid peroxidation, an important process associated with oxidative stress and inflammation. This compound is suitable for research applications involving the modulation of lipoxygenase activity and the investigation of related pathophysiological conditions. -
12-LOX Inhibitor
NCTT-956 is a selective inhibitor of 12-lipoxygenase (12-LOX), primarily targeting its enzymatic activity. This compound demonstrates potent inhibition of 12-LOX, which plays a critical role in various inflammatory processes and platelet function. NCTT-956 is valuable for research applications exploring the mechanisms of lipid-mediated signaling and the development of therapeutic strategies for inflammation-related diseases. -
5-LOX Inhibitor
1-Naphthyl 3,5-dinitrobenzoate is a selective inhibitor of 5-lipoxygenase (5-LOX), demonstrating potent activity with an IC50 of 1.04 µM for 5-LOX and 3.6 µM for mPGES-1. This compound exhibits strong anti-inflammatory properties, evidenced by its IC50 value of 8.6 μM in human whole blood assays. It is a valuable tool for investigating the mechanisms of inflammation and exploring therapeutic strategies targeting leukotriene synthesis. -
Lipoxygenase Inhibitor
(-)-Dihydroguaiaretic acid is a potent lipoxygenase inhibitor that exhibits significant antioxidant properties. It effectively inhibits the oxidation of unsaturated fatty acids and scavenges free radicals, contributing to its protective effects. Additionally, this compound demonstrates anticancer activity with an IC50 value of 7.49 μM in A549 human lung adenocarcinoma cells, making it a valuable tool for cancer research and oxidative stress studies. -
Lipoxygenase Inhibitor
15(S)-HETRE is a lipoxygenase inhibitor, specifically targeting 5-lipoxygenase (5-LO) derived from dihomo-γ-linolenic acid through 15-lipoxygenation. It demonstrates significant inhibitory activity in human polymorphonuclear leukocytes (PMNL) with an IC50 of 4.6 μM. Additionally, in rat basophilic leukemia (RBL) cells, 15(S)-HETRE effectively inhibits 5-LO, albeit with approximately one-twentieth the potency compared to 15(S)-HpETE. This compound is utilized in research applications focused on inflammatory processes and leukotriene synthesis. -
Lipoxygenase Inhibitor
Ro 3-1314 is a potent lipoxygenase inhibitor, specifically targeting the metabolism of linoleic acid. This compound demonstrates significant biological activity by stimulating antigen-induced contraction in guinea-pig tracheal spirals and promoting the immunological release of slow reacting substance of anaphylaxis (SRS-A) from sensitized guinea-pig lung fragments. Ro 3-1314 is valuable for research applications focused on inflammation and respiratory responses. -
Arachidonic Acid 5-Lipoxygenase Inhibitor
BW B70C is a potent and selective inhibitor of arachidonic acid 5-lipoxygenase, demonstrating oral bioactivity. It effectively inhibits both acute and allergic bronchoconstriction, as well as late-phase eosinophil accumulation following allergen exposure in guinea pigs. BW B70C prevents the synthesis of leukotriene C4 and modulates leukocyte migration to the airway lumen, along with reducing albumin microvascular leakage. This compound holds promise for research into anti-asthmatic agents and related inflammatory conditions. -
5-LOX Inhibitor
5-LOX-IN-1 is a potent inhibitor of human 5-Lipoxygenase (5-LOX) with an IC50 value of 2.3 μM. This compound is essential for studying inflammatory pathways and the role of 5-LOX in various inflammatory diseases. Its inhibition of 5-LOX provides a valuable tool for research into therapeutic strategies targeting inflammation. -
Lipoxygenase Inhibitor
3-Chloroiminodibenzyl is a potent dual inhibitor of secreted human lipoxygenase (sHE) and 5-lipoxygenase (5-LOX). It exhibits inhibitory activity with IC50 values of 140 μM and 6.5 μM, respectively. This compound is utilized in research applications focusing on lipid signaling and inflammation pathways, making it valuable for studies related to inflammatory diseases and related therapeutic developments. -
Lipoxygenase Inhibitor
(±)15-HEDE is a racemic mixture comprised of the monohydroxy fatty acids 15(R)-HEDE and 15(S)-HEDE, derived from eicosadienoic acid within macrophages. This compound acts as a selective inhibitor of 5-lipoxygenase (5-LO) with an IC50 value of 35 μM. 15-HEDE is utilized in research to investigate lipoxygenase pathways and their implications in inflammatory processes. Its inhibitory effects on 5-LO make it a valuable tool for studying the modulation of leukotriene biosynthesis and related biological activities. -
5-Lipoxygenase Inhibitor
ZD 2138 is a selective inhibitor of 5-lipoxygenase, an enzyme involved in the production of leukotrienes, which play a significant role in inflammation and bronchoconstriction. This compound has demonstrated potential in alleviating aspirin-induced bronchoconstriction, making it a valuable tool in asthma research and studies focused on respiratory disorders. Its application in modulating inflammatory pathways positions ZD 2138 as an important reagent for investigating therapeutic strategies in related pulmonary conditions. -
Lipoxygenase Inhibitor
Enazadrem is a potent inhibitor of 5-lipoxygenase, an enzyme involved in the inflammatory response. It exhibits significant anti-inflammatory activity, making it a valuable tool for research in fields such as immunology and cancer therapy. This compound aids in the elucidation of pathways related to leukotriene synthesis and may contribute to the development of therapeutic strategies targeting inflammation-related diseases. -
5-Lipoxygenase Inhibitor
TA-270 is a potent inhibitor of 5-lipoxygenase, an enzyme involved in the biosynthesis of leukotrienes, which are key mediators in inflammatory processes. This quinolinone derivative is primarily utilized in asthma research to elucidate the role of leukotrienes in airway inflammation and hyperreactivity. Its selective inhibition of 5-lipoxygenase provides a valuable tool for investigating therapeutic strategies aimed at respiratory conditions. -
5-lipoxygenase inhibitor
HZ52 is a reversible inhibitor of 5-lipoxygenase, effectively blocking leukotriene synthesis with an IC50 of 0.7 μM in intact human polymorphonuclear leukocytes. This compound is valuable for research applications aimed at understanding inflammatory responses and the role of leukotrienes in various diseases. HZ52 may be useful in exploring therapeutic strategies for conditions such as asthma, arthritis, and other inflammatory disorders. -
5-Lipoxygenase Inhibitor
AHR-5333 is a selective inhibitor of 5-lipoxygenase, primarily targeting human blood neutrophils. This compound demonstrates significant and prolonged activity in in vivo models of immediate hypersensitivity, specifically in rats and guinea pigs. AHR-5333 is applicable in research related to inflammatory responses and may provide insights into therapeutic strategies for conditions associated with leukotriene overproduction. -
5-Lipoxygenase Inhibitor
5-LOX-IN-3 is a potent inhibitor of 5-Lipoxygenase, exhibiting an IC50 of less than 1 μM. This compound is valuable for research focused on inflammatory diseases, cancer, stroke, and Alzheimer’s disease, allowing for the exploration of its therapeutic potential in modulating inflammatory pathways. 5-LOX-IN-3 serves as a useful tool in the study of these critical health conditions. -
5-LOX Inhibitor
Tagorizine is a potent inhibitor of 5-lipoxygenase (5-LOX), a key enzyme in the leukotriene biosynthesis pathway. This reagent is valuable for studying vascular biology, particularly in examining cerebral and peripheral blood vessel dilation. Its inhibitory properties make it useful for research into inflammatory responses and related vascular conditions. -
5-LOX Inhibitor
5,6-Dehydroarachidonic acid is an inhibitor of 5-lipoxygenase (5-LOX), targeting the enzymatic pathway responsible for leukotriene biosynthesis. This compound effectively reduces leukotriene production, making it valuable for studies related to inflammation and related pathologies. It has been noted that 5,6-Dehydroarachidonic acid does not influence vascular cell proliferation, highlighting its specificity in research applications. -
5-lipoxygenase Inhibitor
WY-50295 is a selective inhibitor of 5-lipoxygenase, impacting the biosynthesis of leukotrienes. It demonstrates an IC50 of 40 μM in inhibiting LTB4 formation in rat whole blood leukocytes, with an oral ED50 of 18 mg/kg. This compound is valuable for studying asthma and other conditions associated with leukotriene signaling. -
15-Lipoxygenase Inhibitor
Caffeoylcalleryanin is a potent inhibitor of 15-lipoxygenase, exhibiting an IC50 value of 1.59 µM. This compound demonstrates a strong capability to modulate lipid metabolism by inhibiting the action of lipoxygenases, crucial for the biosynthesis of lipid mediators. Caffeoylcalleryanin is suitable for research applications focusing on inflammatory pathways and the study of lipid-related processes. Additionally, it shows no cytotoxic effects, making it a valuable tool for cellular and molecular biology studies.
