AhR

Cat. No.

A64071

CAS No.

2247950-42-9

IK-175

Synonyms: AHR antagonist 5 free base

IK-175 is a selective aryl hydrocarbon receptor (AHR) inhibitor that prevents the translocation of AHR from the cytoplasm to the nucleus. This compound exhibits high specificity for AHR, distinguishing itself from other receptors, transporters, and kinases. IK-175 is primarily used in research applications focused on studying AHR-related pathways and their implications in various diseases, including cancer and immune responses.

Cat. No.

A64074

CAS No.

2247950-73-6

KYN-101

KYN-101 is a selective AHR inhibitor that is potent and orally active. This compound effectively reduces CYP1A1 mRNA expression, contributing to its role in mediating anti-cancer activity. Researchers can utilize KYN-101 to investigate the therapeutic potential in cancer biology and the modulation of AHR-related signaling pathways.

Cat. No.

A64079

CAS No.

149-30-4

2-Mercaptobenzothiazole

2-Mercaptobenzothiazole is an activator of the aryl hydrocarbon receptor (AhR), functioning as an inhibitor of thyroid hormone synthesis and dopamine beta-hydroxylase activity. This compound promotes the invasion of bladder cancer cells by activating AhR transcription and upregulating the expression of CYP1A1 and CYP1B1, implicated in carcinogenesis. Additionally, 2-Mercaptobenzothiazole exhibits inhibition of thyroid peroxidase activity with an IC50 of 11.5 μM and induces significant histological changes in Xenopus laevis, including delayed metamorphosis. It also increases chromosomal aberrations in Chinese hamster ovary cells and inhibits norepinephrine synthesis in murine models, demonstrating its relevance in carcinogenic studies and neurobiological research.

Cat. No.

A64080

CAS No.

38821-49-7

Carbidopa monohydrate

Synonyms: (S)-(-)-Carbidopa monohydrate

Carbidopa monohydrate is a selective inhibitor of peripheral decarboxylase, acting as a modulator of the aryl hydrocarbon receptor (AhR). It exhibits significant biological activity in inhibiting pancreatic cancer cell proliferation and tumor growth, making it a valuable compound for research in cancer biology and neurodegenerative diseases, particularly Parkinson's disease. Its unique mechanism of action allows for exploration in therapeutic strategies targeting AhR-related pathways.

Cat. No.

A64102

CAS No.

2247951-12-6

AHR-IN-1

AHR-IN-1 is a selective aryl hydrocarbon receptor (AHR) inhibitor, exhibiting an IC50 of less than 0.5 μM. This compound is useful for investigating the role of AHR in various biological processes, including immune response modulation and xenobiotic metabolism. AHR-IN-1 serves as a valuable tool for researchers studying the mechanisms by which AHR influences cellular signaling and gene expression.