Succinate Dehydrogenase (SDH)

SDH inhibitors block mitochondrial complex II, the enzyme that oxidizes succinate to fumarate. Succinate dehydrogenase (SDH) links the tricarboxylic acid cycle to the respiratory chain by passing electrons to ubiquinone. A 2005 crystal structure of porcine complex II resolved its four subunits and the ubiquinone-binding site. In 2000, germline mutations in the gene for its D subunit were linked to hereditary paraganglioma. Fluxapyroxad and isofetamid are carboxamide-type fungicides that occupy the ubiquinone-binding site. Siccanin and harzianopyridone are natural products listed as SDH inhibitors. 3-Nitropropanoic acid inactivates the enzyme irreversibly and is used to model striatal neurodegeneration in rodents. Numbered compounds such as SDH-IN-3 and SDH-IN-7 complete the set.

12 Items

  • Fluxapyroxad
    Cat. No.
    A22073

    Fluxapyroxad

    Fluxapyroxad, a broad-spectrum fungicide, is an inhibitor of the succinate dehydrogenase (SQR) enzyme.

    50 mg
    $40.00
    100 mg
    $75.00
    All 3 sizes
  • 3-Nitropropanoic acid
    Cat. No.
    A22454

    3-Nitropropanoic acid

    Synonyms: β-Nitropropionic acid; Bovinocidin

    3-Nitropropanoic acid (β-Nitropropionic acid) is an irreversible inhibitor of succinate dehydrogenase. 3-Nitropropanoic acid exhibits potent antimycobacterial activity with a MIC value of 3.3 μM.

    50 mg
    $25.00
    100 mg
    $35.00
    All 6 sizes
  • SDH-IN-38
    Cat. No.
    A27232

    SDH-IN-38

    SDH-IN-38 is a potent inhibitor of succinate dehydrogenase, primarily targeting mycelial respiration. Demonstrating significant antifungal activity, SDH-IN-38 exhibits an EC50 value of 0.009 μg/mL against R. solani mycelia, effectively inhibiting mycelial growth. Additionally, this compound induces cellular senescence and reduces mitochondrial membrane potential in fungal cells, making it a valuable tool for research in fungal biology and disease management.

    Out of stock

    All 3 sizes
  • Siccanin
    Cat. No.
    A27607

    Siccanin

    Siccanin is a potent inhibitor of succinate dehydrogenase (SDH), exhibiting an IC50 of 0.9 μM with selective activity across species. In addition to its role as an SDH inhibitor, Siccanin demonstrates antimicrobial properties against pathogenic fungi. This compound is valuable for research applications focused on metabolic processes and the treatment of fungal infections.

    1 mg
    $580.00
    5 mg
    $2,215.00
    All 2 sizes
  • SDH-IN-7
    Cat. No.
    A27612

    SDH-IN-7

    SDH-IN-7 is a potent inhibitor of succinate dehydrogenase (SDH), exhibiting an IC50 of 26 nM against porcine SDH. This compound demonstrates significant fungicidal activity, making it a valuable tool for research applications focused on mitochondrial metabolism and fungal pathogenicity. Its inhibitory effect on SDH suggests potential implications in cancer research and metabolic studies.

    Out of stock

    All 3 sizes
  • SDH-IN-3
    Cat. No.
    A27838

    SDH-IN-3

    SDH-IN-3 is a potent inhibitor of succinate dehydrogenase (SDH), demonstrating an IC50 of 7.2 μg/mL. This compound exhibits significant antifungal activity against Nigrospora oryzae, with an EC50 of 1.9 μg/mL. SDH-IN-3 is suitable for research applications focused on anti-infection studies and the modulation of metabolic pathways in fungal pathogens.

    Out of stock

    All 3 sizes
  • Harzianopyridone
    Cat. No.
    A27850

    Harzianopyridone

    Harzianopyridone is a potent inhibitor of succinate dehydrogenase (SDH), exhibiting an IC50 of 80 nM. Isolated from the fungus Trichoderma harzianum, this compound demonstrates significant antifungal, antibacterial, and herbicidal properties. Harzianopyridone is valuable for research applications exploring metabolic modulation and the study of fungal and bacterial pathways.

    0.25 mg
    $110.00
    1 mg
    $380.00
    All 2 sizes
  • Succinate dehydrogenase-IN-8
    Cat. No.
    A28035

    Succinate dehydrogenase-IN-8

    Succinate dehydrogenase-IN-8 is a potent inhibitor of succinate dehydrogenase (SDH). This indene amino acid derivative exhibits significant antifungal activity in vitro, with effective concentrations against Rhizoctonia solani (EC50=0.1843 mg/L), Botrytis cinerea (EC50=0.4829 mg/L), and Sclerotinia sclerotiorum (EC50=0.1349 mg/L). It is a valuable tool for research applications focused on inhibiting SDH in microbial pathogens.

    Out of stock

    All 3 sizes
  • SDH-IN-8
    Cat. No.
    A28116

    SDH-IN-8

    SDH-IN-8 is a potent inhibitor of succinate dehydrogenase (SDH), demonstrating an IC50 value of 27 nM in porcine SDH assays. This compound exhibits significant fungicidal activity, making it a valuable tool for investigating the role of SDH in fungal metabolism and potential therapeutic applications in fungal infections. Researchers may utilize SDH-IN-8 to explore mechanisms of SDH inhibition and its effects on cellular respiration and metabolic pathways.

    Out of stock

    All 3 sizes
  • Isofetamid
    Cat. No.
    A28278

    Isofetamid

    Synonyms: IKF-5411

    Isofetamid is a potent inhibitor of succinate dehydrogenase, primarily utilized as a fungicide. It demonstrates effective control against a range of fungal pathogens, including gray mold, white mold, and powdery mildew. This compound is valuable for research related to plant fungal diseases, contributing to the understanding of fungal inhibition mechanisms and disease management strategies.

    5 mg
    $155.00
    10 mg
    $250.00
    All 3 sizes
  • Diethyl butylmalonate
    Cat. No.
    A38895

    Diethyl butylmalonate

    Diethyl butylmalonate is a competitive inhibitor of succinate dehydrogenase, exhibiting anti-inflammatory properties through the reduction of reactive oxygen species (ROS) production. Additionally, it demonstrates neuroprotective effects, making it a valuable tool in studies related to neurodegenerative diseases, including Alzheimer's disease. Furthermore, Diethyl butylmalonate shows toxicity to Tetrahymena pyriformis, with a log(IGC50-1) value of 0.557, underscoring its potential utility in ecological and cellular toxicity research.

    1 g
    $40.00
    All 1 sizes
  • Flubeneteram
    Cat. No.
    A77880

    Flubeneteram

    Flubeneteram is an inhibitor of succinate dehydrogenase, exhibiting an IC50 value of 0.0484 μM. This compound effectively disrupts the activity of succinate dehydrogenase, contributing to its biological activity. Flubeneteram has demonstrated protective effects against fungal pathogens such as Rhizoctonia solani and Sphaerotheca fuliginea in preclinical studies. It is a valuable reagent for research focused on fungal infection mechanisms and potential therapeutic strategies.

    Out of stock

    All 3 sizes

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