- Cat. No.
- A11534
Pentostatin
Synonyms: Deoxycoformycin
Pentostatin is an irreversible inhibitor of adenosine deaminase (Ki = 2.5 pM).
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- Cat. No.
- A19839
AMPD2 inhibitor 1
AMPD2 inhibitor 1 is an adenosine monophosphate deaminase 2 (AMPD2) inhibitor, used in the research of sugar craving, salt craving, umami craving, and addictions including drug, tobacco, nicotine and alcohol addictions.
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- Cat. No.
- A21585
EHNA hydrochloride
EHNA hydrochloride is a specific inhibitor of adenosine deaminase, prevents dAdo degradation and increases mitochondrial dATP levels in fibroblasts.
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- Cat. No.
- A25272
Hibifolin
Hibifolin is a flavonol glycoside known for its inhibitory action on adenosine deaminase (ADA), with a Ki value of 49.92 μM. It demonstrates neuroprotective properties against β-amyloid-induced neurotoxicity, effectively preventing cell death by blocking Aβ-induced caspase-3 and caspase-7 activation. Additionally, Hibifolin induces Akt phosphorylation in cortical neurons and serves as a natural sortase A (SrtA) inhibitor, exhibiting an IC50 of 31.2 μM. Its antibacterial activities include the attenuation of Staphylococcus aureus pathogenic behaviors, such as adhesion, invasion, and biofilm formation, while also enhancing survival rates in pneumonia models in mice and alleviating associated pathological damages.
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- Cat. No.
- A69310
L-Adenosine
L-Adenosine is a metabolically stable analog that serves as a weak inhibitor of adenosine deaminase (ADA), exhibiting an inhibition constant (Ki) of 385 μM. This compound is valuable for studies involving adenosine uptake and accumulation in biological systems. Its unique properties make L-Adenosine a useful probe for investigating the role of adenosine in various physiological and pathological processes.
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- Cat. No.
- A69311
1-Deazaadenosine
1-Deazaadenosine is a potent inhibitor of adenosine deaminase (ADA), with a Ki value of 0.66 μM. This compound demonstrates significant anti-cancer activity in vitro, indicating its potential utility as a chemotherapeutic agent for lymphoproliferative disorders. Researchers can leverage 1-Deazaadenosine in studies focused on cancer therapeutics and the modulation of adenosine pathways.
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- Cat. No.
- A69312
FR221647
FR221647 is an orally active non-nucleoside inhibitor of adenosine deaminase, specifically targeting the enzyme responsible for the hydrolytic deamination of adenosine. This compound demonstrates a selective inhibitory effect without cytotoxicity at concentrations of 100 μM. It is valuable for research applications related to adenosine signaling and purinergic pathways, providing insights into various physiological and pathological processes.
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- Cat. No.
- A69313
FR234938
FR234938 is a non-nucleoside inhibitor of adenosine deaminase, demonstrating an IC50 of 17 nM for the recombinant human enzyme. This compound exhibits significant anti-rheumatic and anti-inflammatory properties, making it a valuable tool for research in inflammation and immune response modulation. Its selective inhibition of adenosine deaminase offers potential applications in exploring therapeutic strategies for related disorders.
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