- Cat. No.
- A11403
MK-8245
MK-8245 is a Liver-Targeted Stearoyl-CoA Desaturase (SCD) Inhibitor. MK-8245 is useful for the Treatment of Diabetes and Dyslipidemia.
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- Cat. No.
- A12318
SC-26196
Selective δ6 desaturase inhibitor (IC50 = 0.2 μM in vitro).
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- Cat. No.
- A12899
PluriSln 1
stearoyl-CoA desaturase 1 (SCD1) inhibitor. Used to selectively eliminate undifferentiated human pluripotent stem cells (hPSCs) from culture; induces ER stress, attenuates protein synthesis and induces apoptosis in hPSCs. Prevents teratoma formation in immunocompromised mice.
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- Cat. No.
- A13298
A939572
A939572 is a potent, and orally bioavailable stearoyl-CoA desaturase1 (SCD1) inhibitor with IC50 values of
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- Cat. No.
- A15170
MK-8245 Trifluoroacetate
MK-8245 trifluoroacetate is a liver-targeting inhibitor of stearoyl-CoA desaturase (SCD) with IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with anti-diabetic and anti-dyslipidemic efficacy.
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- Cat. No.
- A16936
CAY10566
CAY10566 is a potent and selective inhibitor of SCD1 that demonstrates IC50 values of 4.5 and 26 nM in mouse and human enzymatic assays, respectively.
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- Cat. No.
- A19205
SCD1 inhibitor-1
SCD1 inhibitor-1 is a potent and liver-selective stearoyl-CoA desaturase-1 (SCD1) inhibitor.
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- Cat. No.
- A20150
T-3764518
T-3764518 is a novel and potent stearoyl coenzyme A desaturase (SCD) inhibitor with an IC50 of 4.7 nM.
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- Cat. No.
- A20482
XEN723
XEN723 is a novel and potent thiazolylimidazolidinone inhibitor of Stearoyl-CoA Desaturase (SCD1) with IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively.
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- Cat. No.
- A20820
GSK1940029
Synonyms: SCD inhibitor 1
GSK1940029 (SCD inhibitor 1) is a stearoyl-coa desaturase (SCD) inhibitor extracted from patent WO/2009060053 A1, compound example 16.
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- Cat. No.
- A20963
MF-438
MF-438 is a potent and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor with an EC50 of 2.3 nM for rSCD1.
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- Cat. No.
- A21447
CVT-12012
CVT-12012 is a potent and orally bioavailable stearoyl-coA desaturase (SCD) inhibitor, with IC50s of 38 nM, 6.1 nM for rat microsomal and human HEPG2, respectively.
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- Cat. No.
- A22520
E6446
E6446 is an inhibitor os Toll-like receptor (TLR)7 and 9 signaling.
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- Cat. No.
- A26079
FASN/SCD-IN-1
FASN/SCD-IN-1 is a potent inhibitor of Fatty Acid Synthase (FASN) and Stearoyl-CoA Desaturase (SCD), derived from Silybin. This orally active compound exhibits significant biological activities, including the inhibition of lipid deposition and reduction of FASN and SCD transcription levels. Additionally, FASN/SCD-IN-1 demonstrates antioxidant, anti-inflammatory, and anti-fibrotic properties, with notable hepatoprotective effects in rat models of acute liver injury. Its ability to ameliorate pathological features such as steatosis, inflammation, and fibrosis in mouse models of myeloproliferative steatohepatitis (MASH) makes it a valuable tool for exploring mechanisms underlying MASH-related liver conditions.
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- Cat. No.
- A30192
SSI-4
SSI-4 is a potent stearoyl-CoA desaturase (SCD1) inhibitor with an EC50 of 1.9 nM for mouse SCD1. By blocking the conversion of saturated fatty acids to monounsaturated fatty acids, SSI-4 effectively reduces oleic and palmitoleic acid production. It promotes lipid peroxidation, induces endoplasmic reticulum stress, and activates apoptotic pathways. Additionally, SSI-4 inhibits mTORC1 activity, suppresses B cell proliferation and antibody production, and induces autophagy. This compound is valuable for studies related to cancers such as acute myeloid leukemia and renal cell carcinoma, as well as influenza infections.
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- Cat. No.
- A30605
CVT-11127
Synonyms: GS-456332
CVT-11127 is a potent inhibitor of stearoyl-CoA desaturase (SCD), which plays a crucial role in lipid metabolism. This compound induces apoptosis and causes cell cycle arrest at the G1/S phase, which may impact cellular proliferation. CVT-11127 is primarily utilized in research related to lung cancer, providing valuable insights into therapeutic strategies targeting SCD pathways.
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- Cat. No.
- A47998
Elemicin
Elemicin is a potent inhibitor of Stearoyl-CoA Desaturase 1 (SCD1), acting through metabolic activation. This compound exhibits a range of biological activities, including anti-influenza, antimicrobial, antioxidant, and antiviral effects. Its mechanism and diverse applications make Elemicin a valuable reagent for research in metabolic studies and infectious disease treatment. Caution is advised, as Elemicin and its reactive metabolite, 1′-Hydroxyelemicin, may induce hepatotoxicity.
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- Cat. No.
- A54262
SNX7
SNX7 is a selective inhibitor of the Cyclin-Dependent Kinase Inhibitor (CDKI) pathway. This compound plays a crucial role in studying cellular senescence and various CDKI-related diseases. By targeting the CDKI pathway, SNX7 serves as a valuable tool in cancer research and other conditions where cell cycle regulation is disrupted.
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- Cat. No.
- A77848
Sterculic acid
Sterculic acid is a selective inhibitor of stearoyl-CoA desaturase-1 (SCD1), targeting the delta-9 desaturase (Δ9D) activity. It demonstrates significant inhibitory potency with an IC50 value of 0.9 μM. This compound is useful in studies exploring metabolic disorders, lipid metabolism, and the role of SCD1 in various disease states.
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- Cat. No.
- A77849
SCD1 inhibitor-4
SCD1 inhibitor-4 is a selective inhibitor of stearoyl-CoA desaturase-1 (SCD1) with potent oral bioavailability. This compound is primarily utilized in research focused on metabolic disorders, particularly in the study of diabetes. Its ability to modulate lipid metabolism makes it a valuable tool for investigating the role of SCD1 in adipogenesis and insulin sensitivity.
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- Cat. No.
- A77850
YTX-465
YTX-465 is a potent inhibitor of stearoyl-CoA desaturase (Ole1/SCD), demonstrating IC50 values of 0.039 μM for Ole1 and 30.4 μM for SCD1. This compound is instrumental in studying the biochemical pathways involved in Parkinson's disease and other synucleinopathies. Its ability to modulate Ole1 and SCD1 activity enables a deeper investigation into lipid metabolism and its implications in neurodegenerative conditions.
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- Cat. No.
- A77851
T-3364366
T-3364366 is a reversible, slow-binding inhibitor of delta-5 desaturase (D5D) with sub-nanomolar potency, showing IC50 values of 1.9 nM and 2.1 nM in HepG2 and RLN-10 cell lines, respectively. This compound demonstrates significant inhibitory activity towards D5D (IC50 = 19 nM) while exhibiting excellent selectivity against delta-6 desaturase (D6D, IC50 = 6200 nM) and stearoyl-CoA desaturase (SCD, IC50 > 10000 nM). T-3364366 serves as a valuable tool for research into lipid metabolism and related disorders.
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- Cat. No.
- A77852
SCD1/5-IN-1
SCD1/5-IN-1 is a selective inhibitor of stearoyl-CoA desaturase 1 and 5 (SCD1/5), which plays a critical role in lipid metabolism and fatty acid desaturation. This compound demonstrates potential biological activity in modulating lipid profiles and influencing cellular signaling pathways associated with various neurological diseases. SCD1/5-IN-1 is suitable for studies aimed at elucidating the role of SCD enzymes in neurological pathologies and metabolic disorders.
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- Cat. No.
- A77853
SCD1 inhibitor-3
SCD1 Inhibitor-3 is a potent and orally bioavailable inhibitor of stearoyl-CoA desaturase 1 (SCD1). This compound demonstrates significant efficacy in modulating lipid metabolism, making it valuable in the study of metabolic disorders such as obesity, type II diabetes, and dyslipidemia. Additionally, SCD1 Inhibitor-3 may have applications in researching skin conditions, including acne and certain cancers, by influencing cellular lipid profiles.
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- Cat. No.
- A77854
Cbz-L-Trp-OH
Cbz-L-Trp-OH is a competitive inhibitor of stearoyl-CoA desaturase (SCD), exhibiting an IC50 of 2.5 μM and a Ki of 2.1 μM. This compound is valuable for studying lipid metabolism and exploring therapeutic interventions in metabolic disorders. Its ability to selectively inhibit SCD makes it a useful tool for investigating the role of fatty acid desaturation in various physiological and pathological processes.
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