- Cat. No.
- A12276
TOFA
Synonyms: RMI 14514; MDL14514
TOFA (RMI14514;MDL14514) is an allosteric inhibitor of acetyl-CoA carboxylase-α (ACCA ).
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- Cat. No.
- A13134
CP-640186
CP-640186 is an isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively; with improved metabolic stability vs CP-610431.
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- Cat. No.
- A19854
MK-4074
MK-4074 is a liver-specific inhibitor of acetyl-CoA carboxylase ACC1 and ACC2 with IC50 values of approximately 3 nM.
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- Cat. No.
- A20079
ND-646
ND-646 is an orally bioavailable and steric inhibitor of acetyl-CoA carboxylase (ACC) with IC50s of 3.5 nM and 4.1 nM for recombinant hACC1 and hACC2, respectively.
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- Cat. No.
- A20840
Olumacostat glasaretil
Olumacostat glasaretil is a small molecule inhibitor of acetyl coenzyme A carboxylase (ACC).
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- Cat. No.
- A21000
Firsocostat
Synonyms: ND-630; GS-0976; NDI-010976
Firsocostat (ND-630; GS-0976; NDI-010976) is an acetyl-CoA carboxylase (ACC) inhibitor; inhibits human ACC1 and ACC2 with IC50 values of 2.1 and 6.1 nM, respectively.
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- Cat. No.
- A21460
PF-05175157
PF-05175157 is broad spectrum acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 27.0, 33.0, 23.5 and 50.4 nM for ACC1 (human), ACC2 (human), ACC1 (rat), ACC2 (rat), respectively.
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- Cat. No.
- A21808
CP-640186 hydrochloride
Synonyms: CP 640186
CP-640186 hydrochloride is a potent and cell-permeable Acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively.
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- Cat. No.
- A43924
ND-654
ND-654 is a potent and selective inhibitor of acetyl-CoA carboxylase (ACC), exhibiting IC50 values of 3 nM for ACC1 and 8 nM for ACC2. This compound effectively reduces hepatic lipogenesis, diminishes neutrophil recruitment, and enhances the polarization of anti-inflammatory M2 macrophages. ND-654 holds potential for investigations into nonalcoholic steatohepatitis and hepatocellular carcinoma research.
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- Cat. No.
- A43926
CMS-121
CMS-121 is a quinolone derivative that functions as an orally active inhibitor of acetyl-CoA carboxylase 1 (ACC1). It exhibits significant neuroprotective effects, providing protection to HT22 cells against ischemic and oxidative damage, with EC50 values of 7 nM and 200 nM respectively. Additionally, CMS-121 demonstrates potent anti-inflammatory, antioxidative, and renoprotective activities, making it a valuable compound for research in neuroprotection and cellular stress responses.
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- Cat. No.
- A43927
A-908292
A-908292 is a selective inhibitor of acetyl-CoA carboxylase 2 (ACC2), exhibiting an IC50 of 23 nM against human ACC2. This compound is instrumental for studies related to fatty acid metabolism and has applications in metabolic engineering. Additionally, A-908292 features an alkyne group, facilitating copper-catalyzed azide-alkyne cycloaddition (CuAAc) for use in click chemistry methodologies.
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- Cat. No.
- A43928
MEDICA16
MEDICA16 is a potent inhibitor of acetyl-CoA carboxylase and ATP-citrate lyase, targeting key enzymes involved in lipid metabolism. By limiting the availability of acetyl-CoA for acetyl-CoA carboxylase and exerting competitive inhibition on ATP-citrate lyase, MEDICA16 effectively reduces hepatic AMPK activity. This compound is valuable for research in areas such as insulin resistance, hyperlipidemia, and obesity, providing insights into metabolic disorders and potential therapeutic approaches.
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- Cat. No.
- A43930
Acetyl-CoA Carboxylase-IN-1
Acetyl-CoA Carboxylase-IN-1 is a highly selective inhibitor of acetyl-CoA carboxylase (ACC), demonstrating an IC50 value of less than 5 nM. In addition to its potent inhibitory effects on ACC, this compound exhibits antibacterial activity, making it a valuable tool for research in metabolic regulation and infectious diseases. Its specificity and efficacy make Acetyl-CoA Carboxylase-IN-1 suitable for investigations into ACC-related pathways and potential therapeutic applications.
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- Cat. No.
- A43932
Fluazifop-P-butyl
Fluazifop-P-butyl is an acetyl-CoA carboxylase (ACCase) inhibitor primarily used as a selective herbicide against grassy weeds. By disrupting fatty acid synthesis, it effectively inhibits the growth of target species while preserving broadleaf plants. This compound is instrumental in agricultural research and studies related to herbicide resistance mechanisms.
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- Cat. No.
- A43933
Propaquizafop
Propaquizafop is a phenoxyisopropionic acid compound that functions as an acetyl-CoA carboxylase inhibitor. It demonstrates herbicidal activity by disrupting fatty acid biosynthesis in target plants, making it useful in agricultural research for managing unwanted vegetation. This compound is employed to study metabolic pathways related to lipid synthesis and can aid in the development of more effective herbicidal strategies.
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- Cat. No.
- A43940
ACC1/2-IN-2
ACC1/2-IN-2 is a potent inhibitor of acetyl-CoA carboxylases ACC1 and ACC2, displaying IC50 values of 22 nM and 48 nM, respectively. This compound exhibits significant antiproliferative activity, making it a valuable tool for cancer research. Its selective inhibition of ACC1 and ACC2 provides insights into cellular metabolism and potential therapeutic avenues for tumor growth regulation.
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- Cat. No.
- A43941
Moiramide B
Moiramide B is a selective inhibitor of acetyl-CoA carboxylase (ACC) with an IC50 of 6 nM, demonstrating potent enzymatic inhibition. This compound exhibits antibacterial activity, thereby providing a valuable tool for research in metabolic regulation and microbiology. Its application extends to studies exploring ACC's role in lipid metabolism and potential therapeutic approaches against bacterial infections.
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- Cat. No.
- A43943
Tepraloxydim
Tepraloxydim is an acetyl-CoA carboxylase inhibitor that exhibits herbicidal activity. By inhibiting this enzyme, it disrupts fatty acid synthesis in plants, making it effective for weed control. This compound is utilized in agricultural research to investigate mechanisms of herbicide resistance and the role of lipid metabolism in plant development.
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- Cat. No.
- A43944
ACC1/2-IN-3
ACC1/2-IN-3 is a potent inhibitor of Acetyl-CoA Carboxylase 1 and 2 (ACC1/2), exhibiting an IC50 value between 1-10 nM for both targets. This compound is valuable for investigating diseases associated with ACC, particularly metabolic disorders. Its selective inhibition of ACC1 and ACC2 provides a useful tool for research into metabolic pathways and potential therapeutic interventions.
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- Cat. No.
- A43945
Tralkoxydim
Synonyms: PP604; ICIA 0604; FD-4026
Tralkoxydim is an acetyl-CoA carboxylase inhibitor used primarily in agricultural research. This cyclohexanedione herbicide effectively disrupts lipid biosynthesis in plants, offering insights into metabolic pathways and herbicide resistance mechanisms. Its application is valuable for studies related to crop protection and agricultural biotechnology.
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- Cat. No.
- A43946
Cycloxydim
Synonyms: BAS 517-02H
Cycloxydim is an acetyl-CoA carboxylase inhibitor that functions as a cyclohexanedione oxime herbicide. By inhibiting acetyl-CoA carboxylase, it disrupts fatty acid synthesis in targeted organisms. This compound is utilized in agricultural research to study herbicidal activity and the biochemical pathways involved in plant metabolism.
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- Cat. No.
- A43947
ACC1/2-IN-1
ACC1/2-IN-1 is a potent inhibitor of acetyl-CoA carboxylase 1 and 2 (ACC1/2), demonstrating IC50 values of 98.06 nM and 29.43 nM for ACC1 and ACC2, respectively. This compound is valuable for cancer research, as it inhibits fatty acid synthesis, a process often upregulated in tumorigenesis. Researchers can utilize ACC1/2-IN-1 to explore metabolic pathways and investigate therapeutic strategies targeting ACC in cancer cells.
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- Cat. No.
- A43951
ACC-IN-1
ACC-IN-1 is an allosteric inhibitor of acetyl-CoA carboxylase (ACC). By targeting ACC, this compound plays a crucial role in regulating lipid metabolism, thereby potentially improving liver steatosis and reducing inflammation associated with non-alcoholic steatohepatitis (NASH). It serves as a valuable tool for researchers investigating lipid metabolism and its implications in metabolic disorders.
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- Cat. No.
- A43952
ACC1-IN-2
ACC1-IN-2 is a selective inhibitor of acetyl-CoA carboxylase 1 (ACC1), exhibiting an IC50 of 7.3 nM. This compound is utilized in biological research to investigate the role of ACC1 in lipid metabolism and related disorders, including acne pathogenesis. Its potent inhibitory activity makes it a valuable tool for studying ACC1's impact on cellular processes and therapeutic approaches in dermatological research.
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- Cat. No.
- A43953
CP-610431
CP-610431 is a reversible, ATP-uncompetitive inhibitor of acetyl-CoA carboxylase (ACC), acting on both ACC1 and ACC2 isoforms with IC50 values around 50 nM. This compound is valuable for investigating pathways associated with metabolic syndrome, making it a useful tool in metabolic research and the study of fatty acid synthesis regulation. Its isozyme-nonselective nature allows for broader applications in metabolic disease studies.
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