SREBP

Cat. No.

A11230

CAS No.

947303-87-9

PF 429242

PF 429242 is a reversible, competitive inhibitor of sterol regulatory element-binding protein (SREBP) site 1 protease.

Cat. No.

A21386

CAS No.

2248666-66-0

PF429242 dihydrochloride

Synonyms: PF 429242

PF429242 dihydrochloride is a reversible and competitive S1P inhibitor with an IC50 of 175 nM.

Cat. No.

A16121

CAS No.

298197-04-3

Fatostatin Hydrobromide

Synonyms: Fatostatin A

Fatostatin Hydrobromide is an inhibitor of sterol regulatory element-binding protein (SREBP).

Cat. No.

A20841

CAS No.

1269181-69-2

Nicodicosapent

Nicodicosapent is a fatty acid niacin conjugate that is also an inhibitor of the sterol regulatory element binding protein (SREBP), a key regulator of cholesterol metabolism proteins such as PCSK9, HMG-CoA reductase, ATP citrate lyase, and NPC1L1.

Cat. No.

A20911

CAS No.

1046045-61-7

FGH10019

FGH10019 is a novel sterol regulatory element-binding protein (SREBP) inhibitor with IC50 of 1 μM.

Cat. No.

A21153

CAS No.

125256-00-0

Fatostatin

Synonyms: 125B11

Fatostatin (125B11), a specific inhibitor of SREBP activation, impairs the activation of SREBP-1 and SREBP-2.

Cat. No.

A57828

CAS No.

102115-79-7

Pseudoprotodioscin

Pseudoprotodioscin is a furostanoside that inhibits Sterol Regulatory Element-Binding Proteins (SREBPs) and microRNA 33a/b. This inhibition leads to a reduction in the gene expression involved in cholesterol and triglyceride synthesis. Pseudoprotodioscin is valuable for research on lipid metabolism and related cardiovascular diseases.

Cat. No.

A74846

CAS No.

6515-37-3

4'-Hydroxyflavanone

4'-Hydroxyflavanone is an inhibitor of SREBP maturation, impacting lipid synthesis. As a synthetic analogue of flavanone, it demonstrates potential in studies related to hepatic steatosis and dyslipidemia. This compound can be utilized to explore mechanisms of lipid metabolism and associated disorders.

Cat. No.

A74851

CAS No.

2763493-89-4

SREBP/SCAP-IN-1

SREBP/SCAP-IN-1 is a selective inhibitor of the SREBP/SCAP complex, which plays a crucial role in lipid metabolism and cellular cholesterol homeostasis. This compound effectively disrupts the signaling pathway involved in sterol regulatory element-binding protein activation, providing insight into lipid regulation mechanisms. Research applications include investigating metabolic disorders, cardiovascular diseases, and potential therapeutic strategies targeting cholesterol metabolism.

Cat. No.

A74854

CAS No.

2763493-94-1

SREBP/SCAP-IN-2

SREBP/SCAP-IN-2 is a selective inhibitor of the SREBP/SCAP complex, which plays a crucial role in lipid metabolism and cellular cholesterol homeostasis. This compound effectively interferes with the activation and function of SREBP, thereby modulating lipid biosynthesis pathways. SREBP/SCAP-IN-2 is valuable for research focusing on metabolic disorders, obesity, and cardiovascular diseases, providing insights into the regulatory mechanisms of lipid metabolism.