Protoporphyrinogen IX Oxidase (PPO)

Cat. No.

A38966

CAS No.

1258836-72-4

Trifludimoxazin

Trifludimoxazin is a protoporphyrinogen oxidase (PPO) inhibitor with herbicidal properties. By targeting PPO, it leads to the accumulation of reactive oxygen species (ROS) and subsequent cell membrane damage, resulting in effective weed death. Trifludimoxazin demonstrates significant efficacy in managing both broadleaf and grass weeds, making it a valuable tool in agricultural research and weed control applications.

Cat. No.

A74462

CAS No.

62476-59-9

Acifluorfen sodium

Acifluorfen sodium is a protoporphyrinogen oxidase (PROTOX) inhibitor that leads to the accumulation of protoporphyrin IX (PPIX). This compound is primarily utilized in agricultural research as a herbicide, where it demonstrates the capacity to induce oxidative damage in target plant species by promoting photooxidative degradation of pigments and lipids. Additionally, its effects on liver tumor induction in rodent models make it a valuable tool for studying tumorigenesis and the mechanisms of oxidative stress.

Cat. No.

A75284

CAS No.

50594-66-6

Acifluorfen

Acifluorfen is a protoporphyrinogen oxidase (PROTOX) inhibitor primarily utilized as a herbicide. It effectively promotes the accumulation of protoporphyrin IX (PPIX), leading to significant photooxidative damage in sensitive plant species. Additionally, Acifluorfen has been shown to induce tumors in rodent liver models, making it relevant for research applications focused on oxidative stress and tumorigenesis.

Cat. No.

A75287

CAS No.

103361-09-7

Flumioxazin

Synonyms: Sumisoya; V-53482

Flumioxazin is a selective inhibitor of protoporphyrinogen oxidase, employed primarily in agricultural applications as an herbicide for crops such as soybean and peanut. In addition to its herbicidal activity, Flumioxazin features a reactive alkyne group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc). This property makes it a valuable reagent in click chemistry, facilitating the synthesis of various bio-conjugates and enabling the development of innovative chemical probes in research settings.

Cat. No.

A75290

CAS No.

42874-03-3

Oxyfluorfen

Oxyfluorfen is a diphenyl ether herbicide that acts primarily as a protoporphyrinogen oxidase inhibitor, disrupting photosynthesis by interfering with chlorophyll synthesis. It effectively controls a range of annual broad-leaved and grass weeds in both pre- and post-emergence applications. Additionally, Oxyfluorfen has been shown to inhibit cell growth and induce DNA damage. Its ecological impact extends to aquatic species, such as Paramisgurnus dabryanus, where it can cause genome-level detrimental effects, including stunted skeletal growth and limb abnormalities.

Cat. No.

A75305

CAS No.

1836-75-5

Nitrofen

Nitrofen is a selective contact herbicide that functions as an inhibitor of retinal dehydrogenase, a member of the aldehyde dehydrogenase (ALDH) family, as well as protoporphyrinogen oxidase. Its primary mechanism involves disrupting the biosynthetic pathways of chlorophyll, leading to effective weed control. Nitrofen is commonly utilized in agricultural research to investigate herbicidal activities and the underlying biochemical mechanisms of herbicide resistance.

Cat. No.

A75325

CAS No.

1220411-29-9

Tiafenacil

Tiafenacil is a potent protoporphyrinogen IX oxidase (PPO) inhibitor, demonstrating IC50 values between 22 to 28 nM across a range of plant species, including Amaranthus tuberculatus, Glycine max, Arabidopsis thaliana, and Brassica napus. This herbicide targets the PPO enzyme, disrupting chlorophyll biosynthesis and leading to plant necrosis. Tiafenacil is employed in agricultural research for developing effective weed management strategies and understanding herbicide action mechanisms.

Cat. No.

A75337

CAS No.

122836-35-5

Sulfentrazone

Sulfentrazone is a phenyl triazolinone herbicide that acts as an inhibitor of protoporphyrinogen oxidase. By disrupting the synthesis of chlorophyll and porphyrins, it leads to the destruction of lipid cell membranes in targeted weed species. This mechanism makes sulfentrazone effective in controlling various broadleaf and grass weed species in agricultural research and crop protection applications.

Cat. No.

A75338

CAS No.

50594-67-7

Acifluorfen-methyl

Acifluorfen-methyl is a potent inhibitor of protoporphyrinogen oxidase (Protox), an essential enzyme in the biosynthetic pathways of heme and chlorophyll. This compound exhibits significant photobleaching activity, making it an effective herbicide. Its unique mechanism of action enables targeted applications in the study of plant physiology and herbicide resistance mechanisms.

Cat. No.

A75362

CAS No.

134605-64-4

Butafenacil

Synonyms: WC-9717; CGA-276854

Butafenacil is a selective inhibitor of protoporphyrinogen oxidase, an enzyme crucial for heme biosynthesis. This herbicide exhibits potent activity against various broadleaf and grassy weeds by disrupting chlorophyll production, leading to plant tissue damage. Its application is significant in agricultural research and the study of plant metabolic pathways.

Cat. No.

A75378

CAS No.

174514-07-9

Fluazolate

Synonyms: Isopropazol; JV-485

Fluazolate is a potent inhibitor of protoporphyrinogen-IX-oxidase (Protox). It specifically targets glyphosate-resistant weeds, effectively disrupting chlorophyll synthesis and leading to plant death. This herbicide is utilized in agricultural research to study herbicide resistance mechanisms and the biosynthetic pathways in plants.

Cat. No.

A75420

CAS No.

3058267-27-6

PPO-IN-19

PPO-IN-19 is a potent inhibitor of protoporphyrin IX oxidase (PPO), exhibiting an IC50 of 124 nM. This compound demonstrates significant herbicidal activity, making it a valuable tool for agricultural research. Its mechanism of action provides insights into PPO-related pathways, facilitating studies on herbicide efficacy and plant biochemical responses.

Cat. No.

A75438

CAS No.

117337-19-6

Fluthiacet-methyl

Fluthiacet-methyl is an isoxazole herbicide that functions as a protoporphyrinogen oxidase (Protox) inhibitor. It effectively inhibits chlorophyll biosynthesis in sensitive plants, particularly in the cotyledons of velvetleaf and cotton, leading to significant electrolyte leakage. Additionally, Fluthiacet-methyl promotes the accumulation of protoporphyrin IX in cotton cotyledons, making it a valuable reagent for research into herbicide mechanisms and plant responses to chemical stressors.

Cat. No.

A75447

CAS No.

3087310-75-3

PPO-IN-21

PPO-IN-21 is a selective inhibitor of protoporphyrinogen IX oxidase (PPO), demonstrating a Ki value of 15.2 nM for Nicotiana tabacum PPO. This compound exhibits effective herbicidal activity against a range of weed species, including both monocots and dicots. PPO-IN-21 is applicable in agricultural research and the development of targeted herbicides.

Cat. No.

A75492

CAS No.

110956-75-7

Pentoxazone

Pentoxazone is a protoporphyrinogen IX oxidase (PPO) inhibitor that acts as an effective herbicide. By inhibiting chlorophyll and heme synthesis, it promotes the accumulation and oxidation of protoporphyrinogen IX, leading to the generation of singlet oxygen that damages cell membranes and induces cell death. Pentoxazone demonstrates significant efficacy in suppressing the fresh weight growth of various weed species, while exhibiting limited activity against weedy rice, making it a valuable tool for research into weed management in direct-seeding rice fields.

Cat. No.

A75512

CAS No.

128639-02-1

Carfentrazone-ethyl

Carfentrazone-ethyl is a selective post-emergence herbicide that acts as a protoporphyrinogen oxidase (Protox) inhibitor, exhibiting an IC50 value of 18 nM against soybean Protox. This compound effectively disrupts the biosynthesis of chlorophyll and heme, leading to the rapid death of susceptible weeds, such as ivy-leaved morning glory and velvetleaf. Its primary applications include the control of broadleaf weeds in various agricultural settings, making it a valuable tool in herbicide research and development.

Cat. No.

A75703

CAS No.

3087063-34-8

HPPD/PPO-IN-1

HPPD/PPO-IN-1 is a dual inhibitor targeting 4-hydroxyphenylpyruvate dioxygenase (HPPD) and protoporphyrinogen oxidase (PPO), exhibiting IC50 values of 0.12 μM and 0.51 μM, respectively, for Arabidopsis thaliana HPPD and Nicotiana tabacum PPO. This compound demonstrates broad-spectrum herbicidal activity against various weed species while maintaining safety for crops such as peanuts and cotton. HPPD/PPO-IN-1 is suitable for research focused on the development of environmentally sustainable herbicides.

Cat. No.

A77389

CAS No.

3034607-58-1

PPO-IN-10

PPO-IN-10 is a selective inhibitor of protoporphyrinogen IX oxidase (PPO), functioning through its 2-phenylpyridine pyrrolidone scaffold. By inhibiting PPO, this compound induces the accumulation of photosensitive protoporphyrin IX, ultimately leading to necrosis in target weed leaves. PPO-IN-10 serves as a valuable tool in research aimed at the development of novel PPO herbicides.

Cat. No.

A77391

CAS No.

1879036-88-0

PPO-IN-2

PPO-IN-2 is a potent inhibitor of protoporphyrinogen IX oxidase, exhibiting a Ki value of 16 nM. This compound effectively disrupts heme biosynthesis by targeting the conversion of protoporphyrinogen IX to protoporphyrin IX. PPO-IN-2 is valuable for research into porphyrias and other disorders related to heme metabolism, providing insights into potential therapeutic strategies.

Cat. No.

A77392

CAS No.

1879036-82-4

PPO-IN-3

PPO-IN-3 is a potent protoporphyrinogen oxidase (PPO) inhibitor, exhibiting a KI value of 0.67 nM. This compound demonstrates effective post-emergence herbicidal activity, making it valuable for agricultural applications aimed at weed control. Its specific mechanism of action provides a useful tool for research into herbicide efficacy and resistance mechanisms.

Cat. No.

A77394

CAS No.

3024668-43-4

Herbicidal agent 2

Herbicidal agent 2 is a protoporphyrinogen oxidase (PPO) inhibitor that demonstrates effective herbicidal activity against a range of broadleaf and monocotyledon weeds. This compound serves as a valuable tool in agricultural research for studying herbicide resistance and developing new weed management strategies. Its targeted mechanism offers insights into the inhibition of crucial enzymatic pathways involved in plant growth and development.

Cat. No.

A77395

CAS No.

103361-04-2

PPO-IN-7

PPO-IN-7 is a potent inhibitor of protoporphyrinogen oxidase (PPO), a key enzyme involved in heme biosynthesis. This compound demonstrates significant herbicidal activity, making it valuable for research applications in plant biology and agricultural chemistry. Its ability to inhibit PPO provides insights into metabolic pathways and offers potential development avenues for herbicide formulations.

Cat. No.

A77396

CAS No.

125727-57-3

PPO-IN-6

PPO-IN-6 is a potent protoporphyrinogen oxidase (PPO) inhibitor that disrupts heme and chlorophyll biosynthesis. By inhibiting PPO activity, PPO-IN-6 can be utilized in cancer research and the investigation of other diseases linked to altered porphyrin metabolism. This compound serves as a valuable tool for studying the biochemical pathways involved in disease progression and therapeutic interventions.

Cat. No.

A77397

CAS No.

3029518-71-3

PPO-IN-15

PPO-IN-15 is a potent inhibitor of protoporphyrinogen IX oxidase (PPO), targeting a key enzyme in the biosynthesis of chlorophyll. This compound demonstrates effective herbicidal activity against resistant weed species, making it a valuable tool in agricultural research. Its selectivity profiles indicate reduced phytotoxicity, particularly in wheat and rice, enhancing crop safety while managing weed populations. This functionality makes PPO-IN-15 suitable for studies aimed at developing sustainable weed management strategies.

Cat. No.

A78023

CAS No.

1482-97-9

2,3-Diaminopropionic acid hydrochloride

2,3-Diaminopropionic acid hydrochloride acts as an inhibitor of polyphenol oxidase (PPO), an enzyme involved in the browning reaction of fruits and vegetables. This compound serves as a key precursor for the synthesis of antibiotics and the siderophore staphyloferrin B. Its ability to modulate PPO activity makes it valuable for research in enzymology and agriculture, particularly in studies aimed at controlling oxidative processes in various biological systems.