We use analytics and advertising cookies, which you can accept or reject; see our privacy policy.

Current choice:

Lipoxygenase

Lipoxygenase (LOX) inhibitors block enzymes that insert molecular oxygen into arachidonic acid and related fatty acids. 5-Lipoxygenase (5-LOX) starts leukotriene synthesis, while 12-LOX and 15-LOX form hydroxylated lipid mediators linked to inflammation and ferroptosis. In 1990, leukotriene synthesis in intact cells was shown to require 5-lipoxygenase-activating protein (FLAP), a membrane partner of 5-LOX. The category covers both points of attack on the leukotriene pathway. Zileuton inhibits 5-LOX directly, whereas MK 886 suppresses leukotriene biosynthesis by binding FLAP. PD146176 is a 15-LOX inhibitor that also appears in ferroptosis research, where lipid peroxidation drives cell death. Baicalein, a flavone from Scutellaria baicalensis roots, is a plant-derived lipoxygenase inhibitor used across several of these models.

2 Items

  • 13(S)-HPOTrE(γ)
    Cat. No.
    A76437
    CAS No.
    121107-97-9

    13(S)-HPOTrE(γ)

    13(S)-Hydroxy-9,11,13-octadecatrienoic acid (13(S)-HPOTrE(γ) is an endogenously formed monohydroxy polyunsaturated fatty acid that serves as a substrate for soybean lipoxygenase-1 (LO-1) involved in the metabolism of γ-linolenic acid. It exhibits inhibitory effects on soybean LO-1 activity at concentrations exceeding 100 μM, and is also a precursor for the synthesis of all four isomers of 6,13-DiHOTrE. This compound is valuable for research focusing on lipoxygenase activity and the biochemical pathways involving PUFA metabolism.

    In stock View Details
    0.1 mg
    $230.00
    0.5 mg
    $1,030.00
    All 2 sizes
  • 1-Stearoyl-2-oleoyl-3-linoleoyl-rac-glycerol
    Cat. No.
    A76469
    CAS No.
    2190-14-9

    1-Stearoyl-2-oleoyl-3-linoleoyl-rac-glycerol

    Synonyms: 1-Stearin-2-olein-3-linolein; TG(18:0/18:1/18:2)

    1-Stearoyl-2-oleoyl-3-linoleoyl-rac-glycerol serves as a substrate for lipoxygenase enzymes, playing a critical role in the formation of bioactive lipids. This compound is involved in various biological processes, including inflammation and cellular signaling pathways. Its application in research includes studies on lipid metabolism and the role of lipoxygenases in disease models.

    In stock View Details
    10 mg
    $185.00
    25 mg
    $445.00
    All 3 sizes

2 Items

Added to your cart

View Cart Checkout

    Loading...