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Oxidative phosphorylation (OXPHOS) inhibitors and uncouplers act on ATP production in mitochondria. In OXPHOS, the respiratory chain pumps protons across the inner mitochondrial membrane, and ATP synthase uses the resulting gradient to make ATP, as the chemiosmotic hypothesis proposed. Inhibitors of single complexes are used to study cells that depend on mitochondrial respiration. Examples here include IACS-010759, a complex I inhibitor tested in models of leukemia and brain cancer, and gboxin, which inhibits OXPHOS in glioblastoma cells. FCCP collapses the proton gradient, and S3QEL 2 suppresses superoxide production at complex III.
Synonyms: EMD 387008 hydrochloride
Imeglimin is the first in a new tetrahydrotriazine-containing class of oral antidiabetic agents, the glimins. It has been shown to act on the liver, muscle and pancreatic ??-cells to uniquely target the key defects of type 2 diabetes.
Synonyms: EMD 387008
Imeglimin is an oxidative phosphorylation blocker that acts to inhibit hepatic gluconeogenesis, increase muscle glucose uptake, and restore normal insulin secretion.
