Phospholipases

Cat. No.

A30051

CAS No.

200933-14-8

m-3M3FBS

m-3M3FBS is a potent activator of phospholipase C (PLC). It effectively stimulates superoxide generation in human neutrophils and enhances intracellular calcium concentrations, leading to inositol phosphate production in diverse cell lines. Additionally, m-3M3FBS has been shown to induce apoptosis in monocytic leukemia cells, making it valuable for studying cellular signaling pathways and apoptosis mechanisms in research applications.

Cat. No.

A61414

CAS No.

50293-91-9

(S)-Albuterol hydrochloride

(S)-Albuterol hydrochloride is a selective muscarinic receptor activator that enhances phospholipase C activity. This compound increases intracellular free calcium levels in airway smooth muscle, making it valuable for research on respiratory physiology and pharmacology. Its ability to modulate calcium signaling pathways makes it useful for studying smooth muscle contraction and respiratory function.

Cat. No.

A63073

CAS No.

2553-17-5

9-Oxononanoic acid

Synonyms: 9-ONA

9-Oxononanoic acid is a potent phospholipase A2 (PLA2) activator that arises as a secondary product of lipid peroxidation. It stimulates the production of thromboxane A2 (TXA2) and promotes platelet aggregation in human blood, making it a valuable tool for studying platelet function and related cardiovascular processes. Its oral bioavailability enhances its utility in various in vivo research applications.

Cat. No.

A74591

CAS No.

923509-20-0

VU534

VU534 is a potent activator of N-acyl phosphatidylethanolamine-specific phospholipase D (NAPE-PLD), exhibiting an EC50 of 0.30 μM. This compound also functions as a dual inhibitor of fatty acid amide hydrolase (FAAH) and soluble epoxide hydrolase (sEH) with IC50 values of 1.2 μM. VU534 enhances efferocytosis in a NAPE-PLD dependent manner, making it a valuable tool for investigating mechanisms related to cardiometabolic diseases.

Cat. No.

A77094

CAS No.

94724-12-6

Compound 48/80

Synonyms: Poly-p-methoxyphenethylmethylamine

Compound 48/80 is a poly-p-methoxyphenethylmethylamine that serves as a selective mast cell activator. It functions at the mast cell membrane by stimulating trimeric G-proteins, leading to degranulation through the activation of phospholipase C and D pathways. This compound is frequently utilized in animal and tissue models for research on mast cell biology and immune responses.

Cat. No.

A77125

CAS No.

923417-09-8

VU533

VU533 is a potent NAPE-PLD activator, with an EC50 value of 0.30 µM. This compound enhances NAPE-PLD activity and promotes efferocytosis in macrophages, making it valuable for investigating mechanisms underlying cardiometabolic diseases. VU533 serves as an important tool for researchers exploring the role of NAPE-PLD in cellular activities and disease progression.