PPAR

Cat. No.

A31673

CAS No.

292615-75-9

CAY10506

CAY10506 is a potent ligand of peroxisome proliferator-activated receptor gamma (PPARγ) that induces cell death and reactive oxygen species (ROS) production through a PPARγ-dependent mechanism. This compound demonstrates radiosensitizing properties, enhancing apoptosis induced by gamma radiation and facilitating caspase-3-mediated cleavage of poly (ADP-ribose) polymerase (PARP). CAY10506 is applicable in cancer research, particularly in studies focused on PPARγ signaling pathways and radiation therapy augmentation.

Cat. No.

A39974

CAS No.

862901-87-9

LT175

LT175 is a dual ligand targeting peroxisome proliferator-activated receptors alpha and gamma (PPARα/γ). As an orally active partial agonist, it exhibits effective receptor affinity with EC50 values of 0.22 μM for hPPARα, 0.26 μM for mPPARα, and 0.48 μM for hPPARγ. LT175 modulates coregulator recruitment, specifically cyclic-AMP response element-binding protein-binding protein and nuclear corepressor 1 (NCoR1), via interaction in the hydrophobic "diphenyl pocket" of PPARγ. This compound demonstrates significant insulin-sensitizing effects while reducing adipogenic activity, making it valuable for research in metabolic disorders.

Cat. No.

A40011

CAS No.

66056-18-6

Glycyrin

Glycyrin is a potent ligand for the peroxisome proliferator-activated receptor gamma (PPAR-γ). This compound has demonstrated the ability to lower blood glucose levels in genetically diabetic mice, indicating its potential role in diabetes research. Additionally, glycyrin exhibits antibacterial properties, making it applicable in studies related to infectious diseases.

Cat. No.

A40013

CAS No.

286390-03-2

9-HEPE

9-HEPE is a PPAR ligand derived from the oxidation of Eicosapentaenoic acid, comprising a racemic mixture of 9(R)-HEPE and 9(S)-HEPE. It enhances fatty acid oxidation, promotes adipogenesis, and increases glucose uptake through the activation of peroxisome proliferator-activated receptors (PPARs) in vivo. This compound is instrumental for research applications focusing on metabolic regulation and disorders related to obesity and insulin sensitivity.

Cat. No.

A40018

CAS No.

1060968-92-4

E17241

E17241 is an inducer of ATP-binding cassette transporter A1 (ABCA1) that significantly enhances ABCA1 protein levels in RAW 264.7 macrophages. It also acts as an agonist for peroxisome proliferator-activated receptors (PPARs), contributing to metabolic regulation. Notably, E17241 has demonstrated the capability to reduce plasma glucose levels and body weight in KKAy diabetic mice subjected to a high-fat and high-glucose diet, making it a valuable reagent for research on lipid metabolism and diabetes management.

Cat. No.

A40028

CAS No.

242473-63-8

SKLB102

SKLB102 is a potent PPARγ ligand that demonstrates high affinity for the nuclear receptor. It effectively reduces fat deposition and offers protective effects against non-alcoholic fatty liver disease (NAFLD) by modulating adipocytokine expression and preventing insulin resistance. This compound is valuable for research focused on metabolic disorders and the regulation of lipid metabolism.

Cat. No.

A40096

CAS No.

227002-04-2

L-764406

L-764406 is a high-affinity non-thiazolidinedione ligand for the peroxisome proliferator-activated receptor gamma (PPARγ). Demonstrating partial agonist activity, L-764406 activates the expression of adipocyte-specific genes, such as aP2, in both chimeric receptors containing the PPARγ ligand-binding domain and in 3T3-L1 cell models. Notably, L-764406 does not exhibit activity with PPARα or PPARδ, making it a selective tool for studying PPARγ-related pathways and their implications in metabolic research.

Cat. No.

A40143

CAS No.

3322-62-1

(E/Z)-Oleamide

Synonyms: Octadec-9-enamide

(E/Z)-Oleamide is a potent ligand for the peroxisome proliferator-activated receptor alpha (PPARα). This compound, derived from the plant Galium aparine L., plays a crucial role in modulating hippocampal plasticity through the transcriptional activation of cyclic AMP response element-binding protein (CREB). Its biological activities include the regulation of feeding and sexual behavior in rodent models, making it significant for research in neurobiology and metabolism.