CGP 12177 hydrochloride is a selective β-Adrenergic receptor (β-AR) ligand, primarily functioning as a β3-AR agonist (Ki = 88 nM) while acting as an antagonist at β1/β2-ARs (Ki = 0.9 nM for β1; Ki = 4 nM for β2). This compound also exhibits partial agonist activity for α1-AR in rat pulmonary artery. Notably, CGP 12177 hydrochloride influences the expression of uncoupling protein and leptin genes in adipose tissues of NMRI mice, making it a valuable tool for research in cardiovascular and metabolic disease mechanisms.
CGP 12177 hydrochloride is a selective β-Adrenergic receptor (β-AR) ligand, primarily functioning as a β3-AR agonist (Ki = 88 nM) while acting as an antagonist at β1/β2-ARs (Ki = 0.9 nM for β1; Ki = 4 nM for β2). This compound also exhibits partial agonist activity for α1-AR in rat pulmonary artery. Notably, CGP 12177 hydrochloride influences the expression of uncoupling protein and leptin genes in adipose tissues of NMRI mice, making it a valuable tool for research in cardiovascular and metabolic disease mechanisms.
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