Fig. 1 · Structure
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Chloroquine dihydrochloride
Antimalarial Agent
Chloroquine dihydrochloride is an antimalarial agent that primarily targets and inhibits autophagy and Toll-like receptors (TLRs). It is widely utilized in the treatment of malaria and rheumatoid arthritis, demonstrating significant anti-inflammatory properties. Additionally, chloroquine dihydrochloride exhibits efficacy against SARS-CoV-2 in vitro, with an EC50 value of 1.13 μM, making it a valuable compound for research in infectious diseases and immune response modulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 3545-67-3 |
| Applications | Antimalarial Agent |
| Formula | C18H28Cl3N3 |
| Molecular Weight | 392.79 |
| SMILES | CC(NC1=CC=NC2=CC(Cl)=CC=C12)CCCN(CC)CC.[H]Cl.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.