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ClpP agonist 1

SaClpP Agonist

ClpP Agonist 1 targets Staphylococcus aureus ClpP (SaClpP) with an EC50 of 1.44 μM, showcasing Kd values of 2.95 μM and 18 μM as determined by isothermal titration calorimetry and bio-layer interferometry, respectively. This compound effectively reduces bacterial load, diminishes the infected area, and enhances histopathological outcomes in mouse models of skin infections. ClpP Agonist 1 is particularly relevant for research focused on methicillin-resistant Staphylococcus aureus (MRSA) skin infections.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Agonist
CAS Number	2761081-10-9
Applications	SaClpP Agonist
Formula	C₂₄H₂₁F₅N₄O
Molecular Weight	476.44
SMILES	O=C1C2=C(N3CCN=C3N1CC4=CC=C(C=C4)C(F)(F)F)CCN(C2)CC5=CC(F)=CC(F)=C5

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.