CO Probe 1 is a highly effective fluorescent carbon monoxide (CO) probe designed for real-time imaging applications. It operates by utilizing the Tsuji-Trost reaction, where CO reduces Pd2+ to Pd0 in the presence of PdCl₂, resulting in the removal of the allyl protecting group and subsequent release of fluorescein. This process allows for a significant fluorescence enhancement of up to 150 times within 20 minutes, exhibiting high selectivity and rapid response with minimal cytotoxicity. CO Probe 1 is particularly valuable for investigating pathological mechanisms associated with CO signaling regulation in conditions such as inflammation, vascular disease, and cancer.
CO Probe 1 is a highly effective fluorescent carbon monoxide (CO) probe designed for real-time imaging applications. It operates by utilizing the Tsuji-Trost reaction, where CO reduces Pd2+ to Pd0 in the presence of PdCl₂, resulting in the removal of the allyl protecting group and subsequent release of fluorescein. This process allows for a significant fluorescence enhancement of up to 150 times within 20 minutes, exhibiting high selectivity and rapid response with minimal cytotoxicity. CO Probe 1 is particularly valuable for investigating pathological mechanisms associated with CO signaling regulation in conditions such as inflammation, vascular disease, and cancer.
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