Columbin is a bioactive diterpenoid furanolactone derived from Calumbae radix, known for its anti-inflammatory and anti-trypanosomal activities. It exhibits selective inhibition of COX-2 with an EC50 of 53.1 μM while showing significantly lower activity on COX-1 (EC50 of 327 μM). This compound is utilized in various research applications aimed at understanding inflammatory pathways and developing strategies against trypanosomiasis.
Columbin is a bioactive diterpenoid furanolactone derived from Calumbae radix, known for its anti-inflammatory and anti-trypanosomal activities. It exhibits selective inhibition of COX-2 with an EC50 of 53.1 μM while showing significantly lower activity on COX-1 (EC50 of 327 μM). This compound is utilized in various research applications aimed at understanding inflammatory pathways and developing strategies against trypanosomiasis.
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