Fig. 1 · Structure
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CP-99994 hydrochloride
NK-1 Receptor Antagonist
CP-99994 hydrochloride is a potent neurokinin-1 (NK-1) receptor antagonist, exhibiting a Ki value of 0.25 nM. This compound has demonstrated efficacy in preventing colorectal sensitization within the context of visceral hypersensitivity. CP-99994 hydrochloride effectively reduces acetic acid-induced colorectal hypersensitivity, particularly in models of bladder-colon cross-sensitization, and mitigates neuroglial interactions and MAPK-p38 phosphorylation linked to visceral hypersensitivity.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 145148-39-6 |
| Applications | NK-1 Receptor Antagonist |
| Formula | C19H26Cl2N2O |
| Molecular Weight | 369.33 |
| SMILES | COC(C=CC=C1)=C1CN[C@@H]2[C@H](C3=CC=CC=C3)NCCC2.Cl.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.