Fig. 1 · Structure
Documents & Downloads
Crobenetine hydrochloride
Na+ Channel Inhibitor
Crobenetine hydrochloride is a selective inhibitor of sodium (Na+) channels that effectively displaces 3HBTX from site 2 of the Na+ channel, demonstrating an IC50 of 49 nM in rat brain synaptosomes. This compound exhibits minimal affinity for other receptors and ion channels, ensuring specificity in its action. Notably, Crobenetine hydrochloride has been shown to protect brain tissue from the harmful effects of focal cerebral ischemia in rodent models, making it valuable for research in neuroprotection and related therapeutic applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 221018-88-8 |
| Applications | Na+ Channel Inhibitor |
| Formula | C25H34ClNO2 |
| Molecular Weight | 416.00 |
| Synonyms | BIII-890 hydrochloride; BIII-890 CL |
| SMILES | OC1=C2C([C@@]3(CCN([C@]([H])(C2)C3(C)C)C[C@H](C)OCC4=CC=CC=C4)C)=CC=C1.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.