Fig. 1 · Structure
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Crobenetine
Na+ Channel Blocker
Crobenetine, a benzomorphan derivative and a potent Na+ channel blocker, selectively targets site 2 of the Na+ channel with an IC50 of 49 nM in rat brain synaptosomes. This compound demonstrates strong use-dependent inhibition while maintaining low binding affinity for other receptors and ion channels. Crobenetine has been shown to protect brain tissue from the harmful effects of focal cerebral ischemia in rodent models, making it a valuable tool for researching neuroprotection and ion channel physiology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Blocker |
| CAS Number | 221019-25-6 |
| Applications | Na+ Channel Blocker |
| Formula | C25H33NO2 |
| Molecular Weight | 379.54 |
| Synonyms | BIII-890; BIII-890 CL free acid |
| SMILES | OC1=C2C([C@]3(C)CCN(C[C@@H](OCC4=CC=CC=C4)C)[C@](C3(C)C)([H])C2)=CC=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.