Fig. 1 · Structure
Documents & Downloads
Cytostatin sodium
PP2A Inhibitor
Cytostatin sodium is a selective inhibitor of protein phosphatase 2A (PP2A) with an IC50 value of 210 nM. This compound demonstrates significant anti-metastatic properties and exhibits potent antitumor activity, promoting apoptosis in cancer cells. Additionally, Cytostatin sodium effectively inhibits the adhesion of B16 melanoma cells to extracellular matrix components such as laminin and collagen, making it a valuable tool for cancer research and therapeutic exploration. As a member of the natural product fosriecin family, it offers unique insights into PP2A-related pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 457070-06-3 |
| Applications | PP2A Inhibitor |
| Formula | C21H32NaO7P |
| Molecular Weight | 450.44 |
| SMILES | O=C1C=C[C@H](C)[C@H]([C@@H](C)CC[C@H](OP(O)(O[Na])=O)[C@@H](C)[C@@H](O)/C=C\C=C/C=C/C)O1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.