Fig. 1 · Structure
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D-Histidine
Anti-biofilm Agent
D-Histidine is an anti-biofilm agent that specifically targets bacterial quorum sensing systems, including the RhlI/RhlR pathway, to inhibit biofilm formation. It functions by non-covalently binding to bacterial regulatory factors or copper ion complexes, leading to the downregulation of quorum sensing-related gene expression and reduction in virulence factors, such as alginate and proteases. Additionally, D-Histidine promotes disintegration of established biofilms and enhances sensitivity to antibiotics, while also serving as an efficient catalyst for salt-induced peptide formation (SIPF), facilitating the condensation of amino acids into dipeptides like dialanine and dilysine.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 351-50-8 |
| Applications | Anti-biofilm Agent |
| Formula | C6H9N3O2 |
| Molecular Weight | 155.16 |
| SMILES | OC([C@H](N)CC1=CN=CN1)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.