Fig. 1 · Structure
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D-threo-PDMP
GCS Inhibitor
D-threo-PDMP is a potent inhibitor of glucoceramide synthase (GCS), effectively reducing the synthesis of glycosphingolipids such as GM3 and GD3. This compound is instrumental in studying cellular mechanisms, as it decreases axon length and branching while inhibiting neurite outgrowth. Additionally, D-threo-PDMP mitigates the adhesion of B16 melanoma cells and protects liver cells from TNF-α-induced apoptosis. Its applications extend to various research areas focusing on glycosphingolipid metabolism and related diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 109836-82-0 |
| Applications | GCS Inhibitor |
| Formula | C23H38N2O3 |
| Molecular Weight | 390.56 |
| SMILES | CCCCCCCCCC(N[C@H](CN1CCOCC1)[C@H](O)C2=CC=CC=C2)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.