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DBCO-PEG2-PFP ester

PROTAC Linkers

DBCO-PEG2-PFP ester is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, enhancing the efficiency of target protein degradation. Its application in PROTAC development makes it a valuable tool for researchers exploring regulated protein degradation pathways in cellular studies.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2304558-23-2
Applications	PROTAC Linkers
Formula	C₃₂H₂₇F₅N₂O₆
Molecular Weight	630.56
SMILES	O=C(N1C2=CC=CC=C2C#CC3=CC=CC=C3C1)CCC(NCCOCCOCCC(OC(C(F)=C(F)C(F)=C4F)=C4F)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.