DCDAPH is a specialized near-infrared fluorescent (NIRF) probe designed for the detection of β-amyloid (Aβ) plaques, with excitation and emission wavelengths of 597 nm and 665 nm, respectively, in phosphate-buffered saline. This compound demonstrates a notably high affinity for Aβ aggregates, with a dissociation constant (Kd) of 27 nM and an inhibition constant (Ki) of 37 nM. DCDAPH is capable of effectively permeating the blood-brain barrier, making it suitable for both in vitro and in vivo studies in Alzheimer's disease research.
DCDAPH is a specialized near-infrared fluorescent (NIRF) probe designed for the detection of β-amyloid (Aβ) plaques, with excitation and emission wavelengths of 597 nm and 665 nm, respectively, in phosphate-buffered saline. This compound demonstrates a notably high affinity for Aβ aggregates, with a dissociation constant (Kd) of 27 nM and an inhibition constant (Ki) of 37 nM. DCDAPH is capable of effectively permeating the blood-brain barrier, making it suitable for both in vitro and in vivo studies in Alzheimer's disease research.
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