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Debio 1453

Bactericidal FabI Inhibitor

Debio 1453 is a potent bactericidal FabI inhibitor targeting N. gonorrhoeae, with an IC50 of 0.6 nM against both sensitive and drug-resistant strains. It effectively hampers bacterial survival by simultaneously inhibiting FabI and engaging the non-mutable NADH cofactor, demonstrating a low propensity for resistance development. Debio 1453 has been shown to clear antibiotic-resistant N. gonorrhoeae infections in murine vaginal models and is valuable for research focused on gonorrhea treatment and bacterial resistance.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2422053-29-8
Applications	Bactericidal FabI Inhibitor
Formula	C₂₃H₂₄N₄O₄
Molecular Weight	420.46
SMILES	CC1=C(OC2=C1C=CC=C2)CN(C(/C=C/C3=CN=C4NC([C@H]([C@H](NC4=C3)C)O)=O)=O)C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.