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Fig. 1 · Structure
Cat. No.
A12864
CAS No.
681492-22-8
Formula
C25H25F3N4O6
Mol. Weight
534.48

Documents & Downloads

Delamanid (OPC-67683)

Antibiotic

Delamanid is a new antituberculosis drug that inhibits mycolic acid synthesis and has shown potent in vitro and in vivo activity against drug-resistant strains of Mycobacterium tuberculosis.

In Stock

Publications for Delamanid

4 publications citing this product

  1. Seungmo Kim, .et al. , Tuberculosis, 2025, 152: 102630 PMID: 40120193
  2. Thanh Quang Nguyen, .et al. , Antimicrob Agents Chemother, 2022, Dec 20;66(12):e0044822 PMID: 36321819
  3. Meikle V, .et al. , Antimicrob Agents Chemother, 2018, Nov 12. pii: AAC.01846-18 PMID: 30420480
  4. World Health Organization, .et al. , World Health Organization, 2018, WHO/CDS/TB/2018.24
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For laboratory research use only. We do not sell to patients.

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Biological Activity

Cellular Effect

Cell Line Activity Value Description Reference
HepG2 CC50 107.5 μg/mL Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay [PMID: 26487912]
MRC5 IC50 > 64 μM Cytotoxicity against human MRC5 cells assessed as cell viability incubated for 72 hrs by fluorimetric assay [PMID: 26901446]
MRC5 IC50 0.43 μM Antitrypanosomal activity against Trypanosoma cruzi infected in human MRC5 cells assessed as parasite growth inhibition incubated for 7 days by chlorophenol red alpha-D-galactopyranoside-based assay [PMID: 26901446]

Specifications

Manufacturer Adooq Bioscience
CAS Number 681492-22-8
Applications

Antibiotic
Formula C25H25F3N4O6
Molecular Weight 534.48
Synonyms OPC-67683
SMILES
C[C@@]1(CN2C=C(N=C2O1)[N+](=O)[O-])COC3=CC=C(C=C3)N4CCC(CC4)OC5=CC=C(C=C5)OC(F)(F)F

Storage & Solubility

In Vitro Solubility

Reported Solubility

SolventReported Solubility
DMSO 85 mg/mL (159.03 mM) Need ultrasonic
Water Insoluble
Ethanol 2 mg/mL

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

In Vivo Preparation

Concentration
2.5 mg/mL (4.68 mM) Need ultrasonic
Vehicle
10% DMSO 40% PEG300 5% Tween-80 45% Saline

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Publications

4 publications citing this product

  1. Seungmo Kim, .et al. , Tuberculosis, 2025, 152: 102630 PMID: 40120193
  2. Thanh Quang Nguyen, .et al. , Antimicrob Agents Chemother, 2022, Dec 20;66(12):e0044822 PMID: 36321819
  3. Meikle V, .et al. , Antimicrob Agents Chemother, 2018, Nov 12. pii: AAC.01846-18 PMID: 30420480
  4. World Health Organization, .et al. , World Health Organization, 2018, WHO/CDS/TB/2018.24

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