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- Meikle V, .et al. A protein complex from human milk enhances the activity of antibiotics and drugs against Mycobacterium tuberculosis, Antimicrob Agents Chemother, 2018, Nov 12. pii: AAC.01846-18 PMID: 30420480
- World Health Organization, .et al. Technical manual for drug susceptibility testing of medicines used in the treatment of tuberculosis, World Health Organization, 2018, WHO/CDS/TB/2018.24
Biological Activity
Delamanid is a new antituberculosis drug that inhibits mycolic acid synthesis and has shown potent in vitro and in vivo activity against drug-resistant strains of Mycobacterium tuberculosis.
| In vitro | DMSO | 85 mg/mL (159.03 mM) | |
| Water | Insoluble | ||
| Ethanol | 2 mg/mL | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.71 mL | 93.55 mL | 187.1 mL |
| 0.5 mM | 3.74 mL | 18.71 mL | 37.42 mL |
| 1 mM | 1.87 mL | 9.35 mL | 18.71 mL |
| 5 mM | 0.37 mL | 1.87 mL | 3.74 mL |
*The above data is based on the productmolecular weight 534.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A12864 |
|---|---|
| CAS No. | 681492-22-8 |
| Formula | C25H25F3N4O6 |
| M. Wt | 534.48 |
| Purity | >98% |
| SMILES | C[[email protected]@]1(CN2C=C(N=C2O1)[N+](=O)[O-])COC3=CC=C(C=C3)N4CCC(CC4)OC5=CC=C(C=C5)OC(F)(F)F |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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