Fig. 1 · Structure
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Dibenzylfluorescein
Cytochrome P450 Substrate
Dibenzylfluorescein is a fluorogenic probe that serves as a substrate for specific cytochrome P450 isoforms, notably CYP3A4, CYP2C8, CYP2C9, CYP2C19, and aromatase (CYP19). This compound, with optimal usage near its Km value of 0.87-1.9 μM (Ex=485 nm, Em=535 nm), is instrumental in assessing alterations in CYP catalytic activity resulting from pharmaceuticals or pathological conditions. Dibenzylfluorescein is widely utilized in drug metabolism studies and toxicity assessments, providing insights into enzyme function in biochemical and pharmacological research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Substrate |
| CAS Number | 97744-44-0 |
| Applications | Cytochrome P450 Substrate |
| Formula | C34H24O5 |
| Molecular Weight | 512.55 |
| Synonyms | DBF |
| SMILES | O=C1C=C2OC3=CC(OCC4=CC=CC=C4)=CC=C3C(C5=CC=CC=C5C(OCC6=CC=CC=C6)=O)=C2C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.