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OP-145

Catalog No.: A49151
Antimicrobial Peptide
OP-145 is a derivative of the antimicrobial peptide cathelicidin LL-37, specifically targeting bacterial pathogens. It exhibits significant antibacterial activity against various strains of MRSA, making it a valuable tool for research in the area of chronic suppurative otitis media. OP-145 can be utilized to explore mechanisms of antimicrobial resistance and potential therapeutic applications in treating resistant infections.
OP-145 732984-81-5 Antimicrobial Peptide
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Research use only. We do not sell to patients.
Data Sheet SDS Compound Handling Instructions

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionOP-145 is a derivative of the antimicrobial peptide cathelicidin LL-37, specifically targeting bacterial pathogens. It exhibits significant antibacterial activity against various strains of MRSA, making it a valuable tool for research in the area of chronic suppurative otitis media. OP-145 can be utilized to explore mechanisms of antimicrobial resistance and potential therapeutic applications in treating resistant infections.
Product Information
Catalog NumA49151
FormulaC142H246N46O31
Molecular Weight3093.76
CAS Number732984-81-5
SequenceAc-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Glu-Arg-Ile-Lys-Arg-Phe-Leu-Arg-Glu-Leu-Val-Arg-Pro-Leu-Arg-NH2
Sequence shorteningAc-IGKEFKRIVERIKRFLRELVRPLR-NH2
SMILESC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CC=CC=C1)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC2=CC=CC=C2)NC([C@@H](NC([C@@H](NC(CNC([C@H]([C@H](CC)C)NC(C)=O)=O)=O)CCCCN)=O)CCC(O)=O)=O)=O)CCCCN)=O)CCCNC(=N)N)=O)[C@H](CC)C)=O)[C@H](C)C)=O)CCC(O)=O)=O)CCCNC(=N)N)=O)[C@H](CC)C)=O)CCCCN)=O)CCCNC(=N)N)=O)=O)CC(C)C)=O)CCCNC(=N)N)=O)CCC(O)=O)=O)CC(C)C)=O)C(C)C)=O)CCCNC(=N)N)(=O)N3[C@H](C(N[C@H](C(N[C@@H](CCCNC(=N)N)C(N)=O)=O)CC(C)C)=O)CCC3
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