DNA Alkylator

Cat. No.

A37312

CAS No.

96892-57-8

Hepsulfam

Synonyms: NCI 329680; ZINC01574758

Hepsulfam is a potent DNA alkylator and crosslinker inducer. It demonstrates significant antileukemic activity, with a median IC50 of 0.91 μg/mL across various tumor types. This compound is primarily utilized in cancer research to investigate mechanisms of DNA damage and repair, as well as to evaluate its potential in therapeutic applications against leukemia.

Cat. No.

A37341

CAS No.

2916559-62-9

Colibactin 742

Colibactin 742 is a potent DNA alkylator and crosslinker inducer that covalently targets DNA, exhibiting an IC50 of 5.2 μM in human cervical cancer cells (HeLa). This compound forms interstrand crosslinks, thereby activating the Fanconi anemia DNA repair pathway and promoting the formation of γH2AX and FANCD2 foci, which can lead to cell cycle arrest. Colibactin 742 serves as a valuable tool for investigations into colorectal cancer, microbial tumorigenesis, DNA damage repair mechanisms, and the study of mutation signatures, effectively mimicking the genotoxic effects of natural Colibactin while providing enhanced stability.

Cat. No.

A37381

CAS No.

2332936-95-3

Anticancer agent 11

Anticancer agent 11 functions as a DNA alkylator and crosslinker inducer, exhibiting broad-spectrum anticancer activity. This compound inhibits angiogenesis and promotes the formation of DNA cross-links, leading to disruptions in DNA replication and repair processes. It has potential applications in cancer research, particularly in the study of tumor biology and the development of novel therapeutic strategies.