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DNA and RNA synthesis inhibitors interfere with nucleic acid replication or transcription by distinct mechanisms. Platinum compounds such as cisplatin, carboplatin and oxaliplatin form DNA adducts, mainly crosslinks between adjacent guanines on the same strand. These adducts block DNA replication and transcription and trigger DNA damage responses. Mitomycin C also crosslinks DNA, but only after reductive activation inside cells. Gemcitabine, a deoxycytidine analog, is incorporated into DNA as its triphosphate and halts chain elongation. CX-5461 acts on transcription, inhibiting synthesis of ribosomal RNA by RNA polymerase I. The protein synthesis inhibitor cycloheximide, which blocks translation elongation on eukaryotic ribosomes, is listed here as well.
Dovitinib-RIBOTAC TFA is a targeted RNA RIBOTAC degrader that specifically binds to and degrades pre-miR-21. This compound demonstrates significant anti-tumor activity and effectively inhibits breast cancer metastasis. It serves as a valuable tool for research involving RNA-targeted degradation and its implications in cancer biology.
