G-quadruplex

Cat. No.

A12380

CAS No.

865311-47-3

Quarfloxin (CX-3543)

Synonyms: CX 3543; Quarfloxacin

Quarfloxin (CX-3543) is a fluoroquinolone derivative with antineoplastic activity. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA (rDNA) template, a critical interaction for rRNA biogenesis that is overexpressed in cancer cells; disruption of this G-quadruplex DNA:protein interaction in aberrant rRNA biogenesis may result in the inhibition of ribosome synthesis and tumor cell apoptosis.

Cat. No.

A14975

CAS No.

794458-56-3

360A

360A is a strong affinity and selectivity inhibitor of G-quadruplex structures.

Cat. No.

A14976

CAS No.

737763-37-0

360A iodide

360A is a strong affinity and selectivity inhibitor of G-quadruplex structures.

Cat. No.

A54683

CAS No.

929895-45-4

Phen-DC3 Trifluoromethanesulfonate

Synonyms: Phen-DC3 Triflate

Phen-DC3 Trifluoromethanesulfonate is a specific ligand that targets G-quadruplex (G4) structures, effectively inhibiting the helicases FANCJ and DinG with IC50 values of 65±6 nM and 50±10 nM, respectively. This compound plays a critical role in research focused on telomere biology, DNA replication, and cancer therapeutics. Its ability to modulate G4 structures makes it a valuable tool for investigating G4-associated cellular processes and the development of novel anti-cancer strategies.