G-quadruplex

Cat. No.

A12380

CAS No.

865311-47-3

Quarfloxin (CX-3543)

Synonyms: CX 3543; Quarfloxacin

Quarfloxin (CX-3543) is a fluoroquinolone derivative with antineoplastic activity. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA (rDNA) template, a critical interaction for rRNA biogenesis that is overexpressed in cancer cells; disruption of this G-quadruplex DNA:protein interaction in aberrant rRNA biogenesis may result in the inhibition of ribosome synthesis and tumor cell apoptosis.

Cat. No.

A22462

CAS No.

1472611-44-1

Pyridostatin TFA salt

Synonyms: Pyridostatin; PDS

Pyridostatin stabilizes G-quadruplexes (G4s) in cells and elicits a DNA damage response by causing the formation of DNA double strand breaks (DSB).

Cat. No.

A14975

CAS No.

794458-56-3

360A

360A is a strong affinity and selectivity inhibitor of G-quadruplex structures.

Cat. No.

A14976

CAS No.

737763-37-0

360A iodide

360A is a strong affinity and selectivity inhibitor of G-quadruplex structures.

Cat. No.

A21727

CAS No.

1781882-65-2

Pyridostatin hydrochloride

Synonyms: RR82 hydrochloride; RR 82

Pyridostatin hydrochloride (RR82 hydrochloride) is a G-quadruplexe stabilizer, with a Kd of 490 nM.

Cat. No.

A30774

CAS No.

2986876-41-7

L5-DA

L5-DA is a selective G-quadruplex stabilizer that preferentially interacts with G4 structures over double-stranded DNA. This compound exhibits notable cytotoxicity against HeLa cells, with an IC50 value of 4.3 μM. L5-DA effectively stabilizes G4s within HeLa cells, leading to the induction of apoptosis and cell cycle arrest. Its role in modulating G-quadruplexes makes it a valuable tool for research in cancer biology and therapeutic development.

Cat. No.

A30807

CAS No.

1639357-93-9

MTR-106

MTR-106 is a potent G-quadruplex stabilizer that also functions as an RNA polymerase I inhibitor. This compound has demonstrated the ability to induce apoptosis and inhibit cell proliferation, making it a valuable tool in cancer research. Its unique mechanism of action provides insights into G-quadruplex dynamics and their implications in tumor biology.

Cat. No.

A32290

CAS No.

741278-95-5

Y502-2304

Y502-2304 is a potent c-Myc G-quadruplex stabilizer that exhibits significant antiproliferative activity in multiple myeloma (MM) cells. It effectively downregulates both c-Myc mRNA and protein expression, leading to the induction of apoptosis characterized by increased γH2AX levels and elevated reactive oxygen species (ROS). Additionally, Y502-2304 disrupts mitochondrial function and demonstrates a marked inhibition of tumor growth in xenograft models of MM. This compound is suitable for various research applications focused on elucidating the molecular mechanisms underlying multiple myeloma.

Cat. No.

A54683

CAS No.

929895-45-4

Phen-DC3 Trifluoromethanesulfonate

Synonyms: Phen-DC3 Triflate

Phen-DC3 Trifluoromethanesulfonate is a specific ligand that targets G-quadruplex (G4) structures, effectively inhibiting the helicases FANCJ and DinG with IC50 values of 65±6 nM and 50±10 nM, respectively. This compound plays a critical role in research focused on telomere biology, DNA replication, and cancer therapeutics. Its ability to modulate G4 structures makes it a valuable tool for investigating G4-associated cellular processes and the development of novel anti-cancer strategies.

Cat. No.

A54686

CAS No.

850559-51-2

BMVC2

Synonyms: o-BMVC

BMVC2 is a bisubstituted carbazole derivative that serves as a G-quadruplex (G4) stabilizer. This compound promotes the formation and stabilization of G-quadruplex structures, which are important in the regulation of gene expression and telomere maintenance. BMVC2 is utilized in research applications focusing on cancer biology, antiviral therapies, and the development of novel molecular therapeutics targeting G4 DNA structures.

Cat. No.

A54689

CAS No.

2517456-88-9

Pyridostatin trihydrochloride

Synonyms: RR82 trihydrochloride

Pyridostatin trihydrochloride is a potent G-quadruplex stabilizer with a binding affinity (Kd) of 490 nM, effectively targeting DNA and RNA G-quadruplex structures within cellular environments. This compound induces growth arrest in human cancer cells through mechanisms involving replication- and transcription-dependent DNA damage. Pyridostatin specifically impacts the proto-oncogene Src, leading to diminished SRC protein levels and reduced SRC-dependent cellular motility in human breast cancer cells. Its applications extend to cancer research, particularly in studying mechanisms of tumor progression and drug resistance.