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RNA/DNA Polymerase

RNA and DNA polymerase inhibitors block enzymes that copy nucleic acid templates in bacteria, viruses and human cells. Rifampin and rifabutin are rifamycins that bind bacterial RNA polymerase and stop the transcript after two or three nucleotides. For RNA viruses, favipiravir serves as a prodrug whose triphosphate form blocks the viral RNA-dependent RNA polymerase. Tenofovir and abacavir block reverse transcriptase, the DNA polymerase of human immunodeficiency virus (HIV). Actinomycin D intercalates into DNA and blocks transcription, and BMH-21 inhibits RNA polymerase I. Fludarabine phosphate, a purine nucleoside analog, inhibits the human DNA polymerases α and δ.

5 Items

  • RNA splicing modulator 6
    Cat. No.
    A27421
    CAS No.
    430443-35-9

    RNA splicing modulator 6

    RNA Splicing Modulator 6 primarily acts as a modulator of RNA splicing. It effectively induces alterations in pre-mRNA splicing, resulting in the accumulation of unspliced RNA, particularly in the Hs-Hsh155 strain. Additionally, RNA Splicing Modulator 6 exhibits significant biological activity by reducing the proliferation of chronic myeloid leukemia cells containing the SRSF2P95H mutation, making it a valuable tool in cancer research and therapeutic studies focused on splicing-related mechanisms.

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    Out of stock

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  • RNA splicing modulator 3
    Cat. No.
    A37896
    CAS No.
    2726461-43-2

    RNA splicing modulator 3

    RNA Splicing Modulator 3 is a selective RNA splicing modulator that exhibits a potent AC50 value of less than 100 nM. This compound is designed to influence splice site selection and modulate alternative splicing events in pre-mRNA. It serves as a valuable tool for investigating the role of RNA splicing in gene expression and its implications in various biological processes and disease states.

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    5 mg
    $300.00
    10 mg
    $495.00
    All 4 sizes
  • RNA splicing modulator 1
    Cat. No.
    A37937
    CAS No.
    2726461-38-5

    RNA splicing modulator 1

    RNA Splicing Modulator 1 is a potent RNA splicing modulator with an AC50 value of less than 100 nM. This compound acts by selectively influencing the spliceosome's activity, thereby affecting mRNA processing. It is valuable for research applications exploring alternative splicing mechanisms and their implications in various biological processes and diseases.

    In stock View Details
    5 mg
    $260.00
    10 mg
    $455.00
    All 4 sizes
  • RNA splicing modulator-4
    Cat. No.
    A38076
    CAS No.
    3067915-73-2

    RNA splicing modulator-4

    RNA Splicing Modulator-4 is a selective agent that targets alternative splicing of precursor mRNA (pre-mRNA) to regulate exon inclusion or exclusion. This compound modifies the coding sequence and functional outcomes of mature mRNAs, facilitating research into pathways relevant to neurodegenerative disorders such as Huntington's disease and various forms of cancer. With its ability to penetrate the blood-brain barrier and oral bioavailability, RNA Splicing Modulator-4 is a valuable tool in the study of RNA splicing mechanisms and their implications in disease.

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    Out of stock

    All 3 sizes
  • RNA splicing modulator 2
    Cat. No.
    A38436
    CAS No.
    2726461-41-0

    RNA splicing modulator 2

    RNA Splicing Modulator 2 functions as an RNA splicing modulator that targets splicing processes within the cell. This compound is utilized to investigate the regulation of gene expression through splicing variations and has potential applications in studies related to cancer, neurodegenerative diseases, and other disorders linked to alternative splicing. Its ability to modulate splicing events makes it a valuable tool for researchers examining the intricacies of RNA biology and therapeutic interventions.

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    Out of stock

    All 3 sizes

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