(-)-Domesticine is an anti-α-1D-adrenoceptor compound with demonstrated cytotoxic activity. It exhibits significant activity in MTS cytotoxicity assays against human colon cancer cell lines, specifically HCT-116 and Caco-2, with IC50 values ranging from 23 to 38 μM, comparable to the cytotoxic agent etoposide. This compound is also amenable to structural modifications, allowing the inclusion of alkoxy substituents and benzoate functional groups at the C1 position, which may enhance its biological activity in various cancer research applications.
(-)-Domesticine is an anti-α-1D-adrenoceptor compound with demonstrated cytotoxic activity. It exhibits significant activity in MTS cytotoxicity assays against human colon cancer cell lines, specifically HCT-116 and Caco-2, with IC50 values ranging from 23 to 38 μM, comparable to the cytotoxic agent etoposide. This compound is also amenable to structural modifications, allowing the inclusion of alkoxy substituents and benzoate functional groups at the C1 position, which may enhance its biological activity in various cancer research applications.
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