Fig. 1 · Structure
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DprE1-IN-1
DprE1 Inhibitor
DprE1-IN-1 is a highly effective inhibitor of DprE1, showing robust biological activity against both drug-susceptible and resistant strains of Mycobacterium tuberculosis. This compound demonstrates favorable hepatocyte stability and low cytotoxicity, making it suitable for further research applications in tuberculosis treatment. Notably, DprE1-IN-1 achieves significant reductions in colony-forming units (CFU) in macrophage assays, underscoring its potential as a therapeutic agent in combating tuberculosis infections.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 920459-41-2 |
| Applications | DprE1 Inhibitor |
| Formula | C19H21N3O6S2 |
| Molecular Weight | 451.52 |
| SMILES | O=C(OCC)NC(C1=C(NC(C2=CC=C(S(=O)(N3CCCC3)=O)C=C2)=O)SC=C1)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.