Fig. 1 · Structure
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DprE1-IN-12
Antitubercular Agent
DprE1-IN-12 is a covalent inhibitor of DprE1, targeting the enzyme involved in the biosynthesis of the Mycobacterium tuberculosis cell wall. It demonstrates significant biological activity with an IC50 value of 0.5 μM, indicating its potency against M. tuberculosis. This compound is valuable for research applications focused on developing antitubercular agents and understanding mechanisms of drug resistance in tuberculosis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 634167-64-9 |
| Applications | Antitubercular Agent |
| Formula | C13H16N4O2 |
| Molecular Weight | 260.29 |
| SMILES | O=[N+](C1=NN(CC2=CC=C(C(C)(C)C)C=C2)C=N1)[O-] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.