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DprE1-IN-9

DprE1 Inhibitor

DprE1-IN-9 is a reversible inhibitor of DprE1, effectively targeting its receptor cavity. This compound exhibits potent antimycobacterial activity, demonstrating a minimum inhibitory concentration (MIC) of 0.18 µg/mL against the non-pathogenic strain H37Ra, as well as strong efficacy against the pathogenic H37Rv and various clinical multidrug-resistant (MDR) and extensively drug-resistant (XDR) isolates. DprE1-IN-9 is valuable for research applications focused on tuberculosis and related infections.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2906099-98-5
Applications	DprE1 Inhibitor
Formula	C₂₂H₂₅F₃N₄O₂
Molecular Weight	434.45
SMILES	O=C(C1=C2OCCN(CC3=NC(C)=C(C)N=C3C)C2=CC(C4CC4)=C1)NCC(F)(F)F

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.