DS79932728 is a potent inhibitor of G9a and GLP, demonstrating IC50 values of 12.6 nM and 75.7 nM, respectively. This compound effectively induces the endogenous production of γ-globin, leading to elevated levels of fetal hemoglobin (HbF) and an increase in the proportion of F-reticulocytes. Its favorable oral absorption properties have been validated in cynomolgus monkey models, making it a valuable tool for research on hematological disorders and therapeutic strategies aimed at enhancing HbF synthesis.
DS79932728 is a potent inhibitor of G9a and GLP, demonstrating IC50 values of 12.6 nM and 75.7 nM, respectively. This compound effectively induces the endogenous production of γ-globin, leading to elevated levels of fetal hemoglobin (HbF) and an increase in the proportion of F-reticulocytes. Its favorable oral absorption properties have been validated in cynomolgus monkey models, making it a valuable tool for research on hematological disorders and therapeutic strategies aimed at enhancing HbF synthesis.
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