Fig. 1 · Structure
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Ecopipam hydrochloride
D1/D5 Antagonist
Ecopipam hydrochloride is a potent and selective antagonist of the dopamine D1 and D5 receptors, with inhibition constants (Ki) of 1.2 nM and 2.0 nM, respectively. This compound demonstrates over 40-fold selectivity against D2, D4, 5-HT, and α2a receptors, with Ki values of 0.98 μM, 5.52 μM, 0.08 μM, and 0.73 μM, respectively. Ecopipam hydrochloride is applicable in research focused on schizophrenia and obesity, providing a valuable tool for studying these conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 190133-94-9 |
| Applications | D1/D5 Antagonist |
| Formula | C19H21Cl2NO |
| Molecular Weight | 350.28 |
| Synonyms | SCH 39166 hydrochloride |
| SMILES | OC1=C(Cl)C=C2C([C@]3([H])[C@@](CCC4=C3C=CC=C4)([H])N(C)CC2)=C1.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.